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Effects of Di-Isononyl Phthalate on Neuropeptide Y Expression in Differentiating Human Neuronal Cells
Biomedical Sciences, Karlstad University, Karlstad, Sweden.
Biomedical Sciences, Karlstad University, Karlstad, Sweden.
Public Health Science, Department of Health Sciences, Faculty of Health, Science and Technology, Karlstad University, Karlstad, Sweden; Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID iD: 0000-0003-0417-1686
Biomedical Sciences, Karlstad University, Karlstad, Sweden.ORCID iD: 0000-0001-9302-2396
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2017 (English)In: Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, E-ISSN 1742-7843, Vol. 120, no 3, p. 218-323Article in journal (Refereed) Published
Abstract [en]

Neuropeptide Y (NPY) is an abundant neuropeptide in the mammalian brain important for behavioural consequences of stress and energy metabolism. We have addressed possible effects of the phthalate DiNP on NPY expression in human SH‐SY5Y cells, a neuronal in vitro differentiation model. Pico‐ to nanomolar doses of DiNP and its metabolite MiNP resulted in decreased NPY mRNA and peptide expression in retinoid‐differentiated cells. Thus, dys‐regulated NPY may be an adverse outcome for exposure to low doses of DiNP in human beings.

Place, publisher, year, edition, pages
Blackwell Publishing, 2017. Vol. 120, no 3, p. 218-323
Keywords [en]
phthlate, DiNP, MiNP, NPY, SH-SY5Y neuroblastoma cells
National Category
Medical and Health Sciences Cell and Molecular Biology
Research subject
Biomedical Sciences; Biomedical Sciences
Identifiers
URN: urn:nbn:se:oru:diva-79055DOI: 10.1111/bcpt.12670ISI: 000394538600016PubMedID: 27625336Scopus ID: 2-s2.0-85009476073OAI: oai:DiVA.org:oru-79055DiVA, id: diva2:1386269
Note

This work was financially supported by The County Council of Värmland.

Retraction

The above article, published online on 13 September 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Kim Brøsen, the Nordic Association for the Publication of BCPT and John Wiley & Sons Ltd. The retraction has been agreed following an investigation into the accuracy of the data acquisition conducted by Karlstad University into the accuracy of the data acquisition, which concluded that manipulation had taken place during tests performed on an ELISA equipment in order to achieve a preferred result.

Available from: 2016-09-05 Created: 2020-01-17 Last updated: 2020-02-03Bibliographically approved

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Rendel, FilipBornehag, Carl-GustafSundström, Birgitta E.Nånberg, Eewa

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