oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Alpha 1-adrenergic activation of brown adipocytes leads to an increased formation of inositol polyphosphates
Department of Metabolic Research, The Wenner-Gren Insitute, University of Stockholm, Stockholm, Sweden.ORCID iD: 0000-0001-8889-5803
Department of Phamacology, Medical College of Virginia, Richmond, USA.
1986 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 195, no 1-2, p. 319-322Article in journal, Letter (Refereed) Published
Abstract [en]

alpha 1-Adrenergic activation of isolated brown adipocytes causes a rapid mobilization of intracellular Ca2+. The cells also respond with an increased turnover of inositol lipids. The present work demonstrates that alpha 1-adrenergic stimulation of brown adipocytes results in phospholipase C-mediated breakdown of phosphatidylinositol bisphosphate to form inositol trisphosphate. The rate of appearance of inositol trisphosphate is sufficiently rapid for it to mediate or contribute to Ca2+ mobilization in these cells.

Place, publisher, year, edition, pages
Elsevier, 1986. Vol. 195, no 1-2, p. 319-322
Keywords [en]
(Brown adipocyte), α1-Adrenoceptor, Inositol polyphosphate, Li+
National Category
Medical and Health Sciences Cell Biology
Research subject
Biomedical Sciences
Identifiers
URN: urn:nbn:se:oru:diva-79047DOI: 10.1016/0014-5793(86)80185-5ISI: A1986AZG3100068PubMedID: 3002856Scopus ID: 2-s2.0-0022533172OAI: oai:DiVA.org:oru-79047DiVA, id: diva2:1386277
Funder
NIH (National Institute of Health), DE-05764NIH (National Institute of Health), AM-32823Magnus Bergvall Foundation
Note

This work was supported by NIH grants nos DE-05764 and AM-32823. E.N. was the recipient of grants from Åqvists fond and Wallenbergs Jubileumsfond and of support from Magnus Bergvalls Stiftelse and The Swedish Natural Science Research Council (to Barbara Cannon and Jan Nedergaard).

Available from: 2013-10-21 Created: 2020-01-17 Last updated: 2020-01-27Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Nånberg, Eewa

Search in DiVA

By author/editor
Nånberg, Eewa
In the same journal
FEBS Letters
Medical and Health SciencesCell Biology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 30 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf