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Na+-dependent, alpha-adrenergic mobilization of intracellular (mitochondrial) Ca2+ in brown adipocytes
The Wenner‐Gren Institute, University of Stockholm, Sweden.
The Wenner‐Gren Institute, University of Stockholm, Sweden.ORCID iD: 0000-0001-8889-5803
The Wenner‐Gren Institute, University of Stockholm, Sweden.
1984 (English)In: European Journal of Biochemistry, ISSN 0014-2956, E-ISSN 1432-1033, Vol. 141, no 1, p. 187-193Article in journal (Refereed) Published
Abstract [en]

The existence and significance of a hormone-sensitive, rapidly mobilizable intracellular pool of Ca2+ in hamster brown-fat cells was investigated with 45Ca2+-labelling techniques. It was shown that such a pool existed and was probably located within the abundant mitochondria. It was rapidly mobilized by norepinephrine (median effective concentration 50 nM) through alpha-adrenergic mechanisms. The mobilization of Ca2+ from the intracellular stores (mitochondria) required the presence of extracellular Na+, but not of Ca2+, K+ or Mg2+. It is concluded that the experiments are in agreement with a hypothesis linking the mobilization of intracellular Ca2+ pools with an alpha-adrenergically-induced increase in plasma membrane Na+ permeability (observed as a membrane depolarization), and a subsequent activation of the mitochondrial Na+/Ca2+ exchange, leading to mobilization of mitochondrial Ca2+ and the mediation of alpha-adrenergic effects as a result of an elevated cytosolic Ca2+ level.

Place, publisher, year, edition, pages
1984. Vol. 141, no 1, p. 187-193
National Category
Medical and Health Sciences Cell Biology
Identifiers
URN: urn:nbn:se:oru:diva-79021DOI: 10.1111/j.1432-1033.1984.tb08173.xISI: A1984SU23900026PubMedID: 6327307Scopus ID: 2-s2.0-0021246649OAI: oai:DiVA.org:oru-79021DiVA, id: diva2:1386799
Note

This work was supported by a grant to Barbara Cannon and J. N. from the Swedish Natural Science Research Council. E.C. is the recipient of a Swedish Institute/British Council reciprocal scholarship.

Available from: 2013-10-21 Created: 2020-01-20 Last updated: 2020-01-23Bibliographically approved

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