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Vitamin A: a drug for prevention of restenosis/reocclusion after percutaneous coronary intervention?
Örebro University, School of Health and Medical Sciences.
Örebro University, Department of Clinical Medicine.
Örebro University, School of Health and Medical Sciences.
2008 (English)In: Clinical Science, ISSN 0143-5221, E-ISSN 1470-8736, Vol. 114, no 1, p. 19-25Article in journal (Refereed) Published
Abstract [en]

The re-establishment of adequate blood flow in a vessel with a reduced lumen due to an atherosclerotic plaque by percutaneous vascular intervention is a well established procedure. However, the long-term outcome of such interventions is negatively influenced by the development of intimal hyperplasia/restenosis. Although extensively researched, this still represents a significant clinical problem. Retinoids, i.e. natural and synthetic derivates of vitamin A, represent a potential therapeutic compound, since they have been shown to influence the vast majority of processes that ultimately lead to reocclusion of the injured vessel. Retinoids exert their effects at the transcriptional level through their nuclear receptors. Targeting multiple processes, i.e. proliferation, migration, extracellular matrix composition and cell differentiation, as well as coagulation/fibrinolysis, should increase their future role in the prevention of restenosis. The purpose of this review is to summarize the diverse effects of retinoids on pathobiological and biological processes activated at sites of vascular injury with particular emphasis on intimal hyperplasia/restenosis after endovascular interventions.

Place, publisher, year, edition, pages
2008. Vol. 114, no 1, p. 19-25
Keywords [en]
Angioplasty; Transluminal; Percutaneous Coronary, Animals, Coronary Artery Disease/pathology/*therapy, Coronary Restenosis/pathology/*prevention & control, Disease Models; Animal, Humans, Muscle; Smooth; Vascular/drug effects/pathology, Vitamin A/*therapeutic use
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-4623DOI: 10.1042/CS20070090PubMedID: 18047466OAI: oai:DiVA.org:oru-4623DiVA, id: diva2:138922
Available from: 2008-10-08 Created: 2008-10-08 Last updated: 2017-12-14Bibliographically approved

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Ocaya, PaulineKrivospitskaya, OlesyaSirsjö, Allan

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