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Gestational diabetes and preeclampsia
Örebro University, Department of Clinical Medicine.
2004 (English)In: European Journal of Obstetrics, Gynecology, and Reproductive Biology, ISSN 0301-2115, E-ISSN 1872-7654, Vol. 113, no 1, p. 12-16Article in journal (Refereed) Published
Abstract [en]

Objective: To determine whether gestational diabetes mellitus (GDM) increases the risk for preeclampsia independent of other risk factors. Study design: The association between GDM and preeclampsia was analyzed in a population of women who had given birth to singletons registered in Swedish Medical Birth Register from 1992 through 1996 (n=430,852). Results: GDM occurred in 0.8% and preeclampsia in 2.9% of all pregnancies. The rate of preeclampsia was higher in the GDM than in the non-GDM group (6.1% versus 2.8%). High age, nullipara, chronic hypertension, kidney disease, and high body mass index (BMI) were all independently associated with increased risk for preeclampsia. Smoking was associated with decreased risk. Adjusted odds ratio for GDM as a risk factor for preeclampsia was 1.61 (95% confidence interval (CI) 1.39–1.86) when prepregnancy BMI, which was a true confounder, was included in the last step of the multiple logistic regression analysis. Conclusions: There is an independent and significant association between GDM and preeclampsia. Obesity is a major confounding factor but could not explain the total excess risk.

Place, publisher, year, edition, pages
2004. Vol. 113, no 1, p. 12-16
Keywords [en]
Adolescent, Adult, Diabetes, Gestational/*complications, Female, Humans, Medical Records, Middle Aged, Obesity, Pre-Eclampsia/*epidemiology/*etiology, Pregnancy, Registries, Retrospective Studies, Risk Factors, Sweden/epidemiology
National Category
Medical and Health Sciences
Research subject
Medicine
Identifiers
URN: urn:nbn:se:oru:diva-4664DOI: 10.1016/j.ejogrb.2003.07.001PubMedID: 15036703OAI: oai:DiVA.org:oru-4664DiVA, id: diva2:138963
Available from: 2008-10-27 Created: 2008-10-27 Last updated: 2017-12-14Bibliographically approved

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Östlund, Ingrid

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