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Relative differences in aryl hydrocarbon receptor-mediated response for 18 polybrominated and mixed halogenated dibenzo-p-dioxins and -furans in cell lines from four different species
Örebro University, Department of Natural Sciences. (Bioanalytisk miljötoxikologi)
Örebro University, Department of Natural Sciences. (Bioanalytisk miljötoxikologi)ORCID iD: 0000-0001-7338-2079
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2007 (English)In: Environmental Toxicology and Chemistry, ISSN 0730-7268, E-ISSN 1552-8618, Vol. 26, no 11, p. 2448-2454Article in journal (Other academic) Published
Abstract [en]

As a consequence of ubiquitous use of brominated organic chemicals, there is a concern for persistent or increasing environmental levels of polybrominated dibenzo-p-dioxins/furans (PBDD/Fs) and mixed polychlorinated and polybrominated dibenzo-p-dioxins/furans (PXDD/Fs). Hence, there is a need to broaden the toxicological and environmental knowledge about these compounds, as a basis for risk assessment. In the study presented here, the relative potencies (REPs) for 18 PBDD/F and PXDD/ F congeners were determined in four dioxin-specific bioassays from different species: dioxin receptor chemically activated luciferase expression assay (DR-CALUX, rat hepatoma cells), TV101L (human hepatoma cells), and GPC.2D (guinea pig adenoma cells), as well as ethoxyresorufin-O-deethylase induction in the fish cell line RTL-W1 (rainbow trout liver cells). The bioassay specific REP factors presented here enable the assessment of the contribution from PBDD/Fs and PXDD/Fs to total 2,3,7,8-tetrachl orodibenzop-dioxin (TCDD) equivalents (TEQs: toxic equivalents), using bioassay analysis. The PBDD/Fs were found to be equally potent as their chlorinated analogues in the three mammalian assays, whereas the PXDD/Fs showed relatively higher potencies. Of special concern were the 2,3,7,8-substituted penta- and tetrahalogenated congeners, for which mean REPs were >= 1. The 2-B-1,3,7,8-CDD (2-bromo-1,3,7,8-tetrachlorodibenzo-p-dioxin) was up to three times more potent than TCDD in individual experiments (on weight basis). The RTL-W1 was less sensitive to the tested compounds with overall 10-fold lower REPs than the mammalian cell lines. Although the REP factors exhibited species-specific differences, overall resembling rank orders of dioxin-like potency were obtained.

Place, publisher, year, edition, pages
2007. Vol. 26, no 11, p. 2448-2454
Keywords [en]
Adenoma/pathology, Animals, Biological Assay, Cell Line, Dioxins/*toxicity, Environmental Pollutants/*toxicity, Furans/*toxicity, Guinea Pigs, Humans, Hydrocarbons; Brominated/toxicity, Hydrocarbons; Halogenated/*toxicity, Liver/*drug effects/pathology, Oncorhynchus mykiss, Rats, Receptors; Aryl Hydrocarbon/*metabolism, Risk Assessment, Tetrachlorodibenzodioxin/toxicity
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Natural Sciences Chemical Sciences Environmental Sciences Environmental Sciences
Research subject
Environmental Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-4714DOI: 10.1897/07-004R.1PubMedID: 17941736OAI: oai:DiVA.org:oru-4714DiVA, id: diva2:139013
Available from: 2008-11-12 Created: 2008-11-12 Last updated: 2017-12-14Bibliographically approved

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Olsman [Takner], HelenaEngwall, Magnusvan Bavel, Bert

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