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Immunohistochemical changes in the expression of HSP27 in exercised human vastus lateralis muscle
Örebro University, School of Health and Medical Sciences. (RISPA)
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2008 (English)In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 194, no 3, p. 215-222Article in journal (Refereed) Published
Abstract [en]

AIM: The role of HSP27 in the adaptive process of skeletal muscle to exercise, especially in humans, is not well understood. The objective of this study was to investigate immunohistochemical changes in HSP27 expression in human vastus lateralis muscle following resistance and endurance exercises.

METHODS: Two different exercise protocols were used: (1) one-leg ergometer cycling (EC, n = 6) consisting of two 30-min bouts at 40% and 75% of peak oxygen uptake, respectively, and (2) leg extension resistance exercise (RE, n = 9) including 10 sets of eight repetitions at a load corresponding to 70% of one maximal repetition (1RM). Immunohistochemistry using specific monoclonal antibodies was used to determine the location of HSP27 protein in muscle biopsies from human vastus lateralis.

RESULTS: Our results show that RE, but not EC, induced a significant appearance of scattered accumulations of HSP27 protein in muscle fibres from five of nine subjects. The number of fibres with accumulation of HSP27 in RE ranged from 0% to 32% with a mean of 6.3% of the total number of fibres.

CONCLUSION: We conclude that this rapid HSP27 protein relocation after RE is an important player in the cellular remodelling of human muscle fibres in response to exercise involving high-force contractions, but not in response to endurance exercises.

Place, publisher, year, edition, pages
2008. Vol. 194, no 3, p. 215-222
National Category
Medical and Health Sciences Physiology
Research subject
Physiology
Identifiers
URN: urn:nbn:se:oru:diva-4751DOI: 10.1111/j.1748-1716.2008.01875.xPubMedID: 18489727OAI: oai:DiVA.org:oru-4751DiVA, id: diva2:139050
Available from: 2008-11-24 Created: 2008-11-24 Last updated: 2018-01-13Bibliographically approved

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Folkesson, MattiasKadi, Fawzi

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School of Health and Medical SciencesSchool of Health and Medical Sciences, Örebro University, Sweden
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