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In response to Point: Counterpoint: "Satellite cell addition is/is not obligatory for skeletal muscle hypertrophy"
Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. (RISPA- MEP-RG)ORCID iD: 0000-0002-9831-0896
2007 (English)In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 103, no 3, p. 1105-1105Article in journal (Other academic) Published
Abstract [en]

In this letter, the point: counterpoint issue (1, 5) is addressed solely by referring to studies in humans. The analysis of histological sections from skeletal muscle of power lifters with many years of practice leaves no doubt about the role of satellite cells as myonuclei donors in the hypertrophied muscle fibre. The larger the cross-sectional area of fibres, the higher the number of myonuclei per cross-section (2, 4). Importantly, the strong relationship between the cross-sectional area of fibres and the number of myonuclei (r = 0,86; p < 0.0001) is obtained with a range of areas between 2500 µm2 and 14000 µm2 (4). Existing myonuclei are able to sustain an initial hypertrophy of the muscle fibre as long as the transcriptional activity of existing myonuclei does not reach its maximum (2, 3, 5). Satellite cells become myonuclei donors when fibre size reaches the ceiling size (2, 3, 5). Additionally, we should not forget that satellite cells are also donors of myonuclei to newly generated myotubes (2, 4). The intensity of exercise and the initial fibre area of the subjects included in a training program are important factors governing whether daughter cells generated by satellite cell activation and proliferation provide new myonuclei to existing myofibres or to newly generated myotubes. Finally, in parallel with these events, some of the daughter cells can escape differentiation and facilitate renewal of the satellite cell pool. Efforts should be made to better understand key elements guiding the fate of satellite cells.

Place, publisher, year, edition, pages
2007. Vol. 103, no 3, p. 1105-1105
Keywords [en]
Humans, Muscle Development/*physiology, Muscle Fibers/*physiology, Muscle; Skeletal/*cytology/physiology, Satellite Cells; Skeletal Muscle/*physiology
National Category
Social Sciences Interdisciplinary Sport and Fitness Sciences Medical and Health Sciences Physiology
Research subject
Sports Science
Identifiers
URN: urn:nbn:se:oru:diva-4756PubMedID: 17982765OAI: oai:DiVA.org:oru-4756DiVA, id: diva2:139055
Available from: 2008-11-24 Created: 2008-11-24 Last updated: 2018-01-13Bibliographically approved

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Kadi, Fawzi

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