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Increasing CSF phospho-tau levels during cognitive decline and progression to dementia
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2008 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 29, no 10, p. 1466-1473Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Little is known about longitudinal changes of cerebrospinal fluid (CSF) biomarkers during cognitive decline in neurodegenerative disease progression.

OBJECTIVE: To investigate longitudinal changes in CSF biomarkers--total-tau (T-tau), phospho-tau (P-tau) and beta-amyloid (Abeta42)--during cognitive decline.

METHODS: Forty memory clinic patients (47.5% females), aged 61.3+/-7.6 (S.D.) years, non-demented at baseline, underwent lumbar puncture and neuropsychological testing at two occasions. Baseline mean MMSE-score was 28.3+/-1.8. Patients were divided into three groups based on baseline memory functioning; severely impaired (SIM), moderately impaired (MIM) and no impairment (NIM).

RESULTS: There was a significant increase in P-tau in the SIM-group during follow-up, while P-tau in MIM and NIM did not change. Eighty-three percent of the SIM-patients converted to dementia (80% AD), while most MIM- and NIM-patients remained non-demented. T-tau- and Abeta42-levels did not change in any of the memory groups during follow-up.

CONCLUSION: Increasing P-tau levels during cognitive decline and conversion to dementia suggest that P-tau may be useful as a longitudinal marker of the neurodegenerative process.

Place, publisher, year, edition, pages
2008. Vol. 29, no 10, p. 1466-1473
National Category
Medical and Health Sciences Neurosciences Physiology Physiology
Research subject
Neurology
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URN: urn:nbn:se:oru:diva-4776DOI: 10.1016/j.neurobiolaging.2007.03.027OAI: oai:DiVA.org:oru-4776DiVA, id: diva2:139075
Available from: 2008-11-27 Created: 2008-11-27 Last updated: 2018-01-13Bibliographically approved

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Engfeldt, Peter

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CiteExportLink to record
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  • apa
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