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Hur säker är ekokardiografi för mätning av LVEF?: Jämförelse mot gated SPECT MPS
Örebro University, Department of Clinical Medicine.
2007 (Swedish)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [sv]

LVEF är en viktig parameter vid bedömning av prognos och behandling vid hjärtsjukdom. Syfte: Syftet var att analysera ekokardiografi och fyra beräkningsmodeller på ekokardiografi (MRR, Teichholtz, Simpsons biplan samt visuell estimering) som metoder att beräkna ett korrekt LVEF-värde samt om ekokardiografi är operatörsberoende. Referensmetoden var gated SPECT.

Patienter/metod: 133 patienter som genomgått ekokardiografi och g-SPECT på universitetssjukhuset i Örebro inom 202 dagar analyserades retrospektivt. Korrelation, signifikans, differens och samband beräknades. Samband illustrerades med Bland-Altman plot. Signifikansen sattes till 0,05 och en godtagbar limit of agreement (medelvärde differens± 2 SD differens) sattes till < 20 LVEF %.

Resultat: Sambandet och korrelationen mellan ekokardiografi och g-SPECT var godtagbart (r=0,779, p<0,001, limits of agreement + 20,8; - 11,6).

Sambandet och korrelationen för beräkningsmodellerna Simpsons biplan metod och visuell estimering på ekokardiografi var godtagbart (r=0,86 respektive 0,79, p<0,001, limits of agreement + 19,1;-5,7 respektive + 19,5;-11,7).

Sambandet och korrelationen för beräkningsmodellerna MRR och Teichholtz på ekokardiografi metod var inte godtagbart (r=0,46 respektive 0,47, p + 30,1;-18,9 respektive + 23,7;-11,1). Ekokardiografi var inte operatörsberoende (p=0,419).

Slutsats: Ekokardiografi har ett godtagbart samband med referensmetoden men sambandet är olika för de olika beräkningsmodellerna på ekokardiografi. Resultatet ska dock betraktas kritiskt då även referensmetoden uppvisar många felkällor.

Abstract [en]

How correct is LVEF calculated by echocardiography?

Comparison with gated SPECT.

LVEF is an important measurement for evaluating prognosis and treatment at heart diseases.

Aim: The aim was to analyse echocardiography and four different models at echocardiography (MRR, Teichholtz, Simpsons biplan and visual estimation) for measuring LVEF value and to investigate if echocardiography is dependent of the echocardiographer. The reference method was gated SPECT (g-SPECT).

Patients/method: 133 patients who had undergone echocardiography and g-SPECT at the university hospital of Örebro within 202 days of each other were analysed retrospectively. The correlation (r), significance (p), difference and agreement between the two methods where calculated. Agreement were visualised by Bland-Altman plot. A p-value of 0,05 were considered significant and an agreement of < 20 LVEF % were considered acceptable.

Results: The agreement and correlation between echocardiography and g-SPECT was acceptable (r=0,779, p<0,001, limits of agreement + 20,8; - 11,6).

The agreement and correlation for the calculation models Simpsons biplan method and visual estimation on echocardiography were acceptable (r=0,86 and 0,79, p<0,001, limits of agreement + 19,1;-5,7 and + 19,5;-11,7).

The agreement and correlation for the calculation models MRR and Teichholtz method on echocardiography was not acceptable (r=0,46 and 0,47, p + 30,1;-18,9 and + 23,7;-11,1). Echocardiography was not dependent on the echocardiographer (p=0,419).

Conclusion: Echocardiography has an acceptable agreement with the reference method but the agreement is different for the different models. The results must be viewed critically since the reference method contains multiple sources of errors.

Place, publisher, year, edition, pages
2007. , 41 p.
Keyword [en]
EF, SPECT, Echocardiography
Keyword [sv]
EF, SPECT, Ekokardiografi
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:oru:diva-4885OAI: oai:DiVA.org:oru-4885DiVA: diva2:139187
Presentation
(English)
Uppsok
Social and Behavioural Science, Law
Supervisors
Examiners
Available from: 2009-07-13 Created: 2009-07-13 Last updated: 2009-12-02Bibliographically approved

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