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TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort
Örebro University, School of Health and Medical Sciences.
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2007 (English)In: Oncogene, ISSN 0950-9232, E-ISSN 1476-5594, Vol. 26, no 31, p. 4596-4599Article in journal (Refereed) Published
Abstract [en]

The identification of the TMPRSS2:ERG fusion in prostate cancer suggests that distinct molecular subtypes may define risk for disease progression. In surgical series, TMPRSS2:ERG fusion was identified in 50% of the tumors. Here, we report on a population-based cohort of men with localized prostate cancers followed by expectant (watchful waiting) therapy with 15% (17/111) TMPRSS2:ERG fusion. We identified a statistically significant association between TMPRSS2:ERG fusion and prostate cancer specific death (cumulative incidence ratio=2.7, P<0.01, 95% confidence interval=1.3–5.8). Quantitative reverse-transcription–polymerase chain reaction demonstrated high estrogen-regulated gene (ERG) expression to be associated with TMPRSS2:ERG fusion (P<0.005). These data suggest that TMPRSS2:ERG fusion prostate cancers may have a more aggressive phenotype, possibly mediated through increased ERG expression.

Place, publisher, year, edition, pages
Basingstoke: Nature Publ. Group , 2007. Vol. 26, no 31, p. 4596-4599
National Category
Medical and Health Sciences Surgery Cancer and Oncology
Research subject
Oncology
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URN: urn:nbn:se:oru:diva-5066DOI: 10.1038/sj.onc.1210237OAI: oai:DiVA.org:oru-5066DiVA, id: diva2:139665
Available from: 2009-01-26 Created: 2009-01-26 Last updated: 2017-12-14Bibliographically approved

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Andrén, OveJohansson, Jan-Erik

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