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Spontaneous axonal regeneration in rodent spinal cord after ischemic injury
Department of NEUROTEC, Huddinge University Hospital, Stockholm, Sweden.ORCID iD: 0000-0002-3845-8100
d Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Stereological Research Laboratory, University of Aarhus and Institute of Pathology, Aalborg Hospital, Aarhus, Denmark.
Department of NEUROTEC, Huddinge University Hospital, Stockholm, Sweden.
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2002 (English)In: Journal of Neuropathology and Experimental Neurology, ISSN 0022-3069, E-ISSN 1554-6578, Vol. 61, no 1, p. 64-75Article in journal (Refereed) Published
Abstract [en]

Here we present evidence for spontaneous and long-lasting regeneration of CNS axons after spinal cord lesions in adult rats. The length of 200 kD neurofilament (NF)-immunolabeled axons was estimated after photochemically induced ischemic spinal cord lesions using a stereological tool. The total length of all NF-immunolabeled axons within the lesion cavities was increased 6- to 10-fold at 5, 10, and 15 wk post-lesion compared with 1 wk post-surgery. In ultrastructural studies we found the putatively regenerating axons within the lesion to be associated either with oligodendrocytes or Schwann cells, while other fibers were unmyelinated. Immunohistochemistry demonstrated that some of the regenerated fibers were tyrosine hydroxylase- or serotonin-immunoreactive, indicating a central origin. These findings suggest that there is a considerable amount of spontaneous regeneration after spinal cord lesions in rodents and that the fibers remain several months after injury. The findings of tyrosine hydroxylase- and serotonin-immunoreactivity in the axons suggest that descending central fibers contribute to this endogenous repair of ischemic spinal cord injury.

Place, publisher, year, edition, pages
American Association of Neuropathologist , 2002. Vol. 61, no 1, p. 64-75
Keywords [en]
Axon, CNS, Global spatial sampling, Ischemia, Neurofilament, Regeneration, Spinal cord injury
National Category
Medical and Health Sciences Neurosciences
Identifiers
URN: urn:nbn:se:oru:diva-80952DOI: 10.1093/jnen/61.1.64ISI: 000173097300007PubMedID: 11829345Scopus ID: 2-s2.0-0036135712&OAI: oai:DiVA.org:oru-80952DiVA, id: diva2:1421110
Available from: 2020-04-02 Created: 2020-04-02 Last updated: 2024-01-02Bibliographically approved

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