Prominent binding of the dopamine D3 agonist [3H]PD 128907 in the caudate-putamen of the adult rat
1999 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 822, no 1-2, p. 126-131Article in journal (Refereed) Published
Abstract [en]
We have analyzed the binding properties of the selective D3 receptor agonist [3H]PD 128907 in 120 days old rats. In tissue sections, we found high numbers of binding sites for [3H]PD 128907 both in the islands of Calleja and the caudate-putamen (Bmax values being 500 and 1000 fmol/mg protein, respectively). The KD values were higher in the caudate-putamen than in the islands of Calleja. Similar regional differences in Bmax and KD values were observed in membranes from the caudate-putamen and the subcortical limbic region. The distribution of [3H]PD 128907 in adult rats is markedly different from that observed in young rats. Taken together, the present results suggest a prominent presence of D3 receptors in the caudate-putamen of adult, but not young, rats. Hence, these findings may have important physiological, pathophysiological, and clinical implications.
Place, publisher, year, edition, pages
Elsevier, 1999. Vol. 822, no 1-2, p. 126-131
Keywords [en]
PD 128907, Dopamine D3 receptor, Binding affinity, Basal ganglia, Caudate–putamen, Islands of Calleja
National Category
Medical and Health Sciences Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:oru:diva-80965DOI: 10.1016/s0006-8993(99)01138-5PubMedID: 10082890Scopus ID: 2-s2.0-0033586251OAI: oai:DiVA.org:oru-80965DiVA, id: diva2:1421164
2020-04-022020-04-022020-04-02Bibliographically approved