Professional teaching requires interdisciplinary competency. In consequence, teacher education programs throughout the world generally compile a comprehensive list of disciplines and knowledge practices required for professional work and teachers’ continuing education. As student teachers need to be offered opportunities to make linkages between collected disciplines, concepts and practices have to be structurally interconnected through a coherent program. Coherence is about connecting what belongs together, that is, establishing systemic relations between the constituent parts of teacher education. In this chapter, we elaborate a conceptual framework outlining how the issue of knowledge integration in teacher education programs may be understood and investigated through the lens of coherence. Our focus is on the conceptual coherence in interdisciplinary teacher education programs, as well as on the structural coherence of organizing disciplinary knowledge in and across subject studies, subject didactic areas, and educational science. The analysis is anchored in recent research studies evaluating Swedish programs for teacher education, where relationships between national guidelines, interpretations made by institutions of higher education, and the perceptions of teacher educators and student teachers have been studied in relation to the issue of coherence.