Regional roles of universities in the Global South have been under-explored, and it is not clear how relevant are concepts originating from the Global North when applied in this context. The paper interrogates the concept of the ‘entrepreneurial university’ and its regional impact and engagement via a case study in Brazil. It is found that, in addition to purely entrepreneurial and economic activities and roles, initiatives relating to social innovation and entrepreneurship to solve profound regional problems are a key part of the university’s work.