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Sponge Spray-Reaching New Dimensions of Direct Sampling and Analysis by MS
University of Tartu, Tartu, Estonia.ORCID iD: 0000-0003-2911-424X
University of Tartu, Tartu, Estonia; University of Helsinki, Helsinki, Finland.ORCID iD: 0000-0002-2541-0132
University of Tartu, Tartu, Estonia.
University of Tartu, Tartu, Estonia.
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2017 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 89, no 21, p. 11592-11597Article in journal (Refereed) Published
Abstract [en]

Sample preparation for the analysis of clinical samples with the mass spectrometer (MS) can be extensive and expensive. Simplifying and speeding up the process would be very beneficial. This paper reports sponge spray-a novel sampling and direct MS analysis approach-attempting exactly that. It enables direct analysis without any sample preparation from dried blood, plasma, and urine. The tip of a volumetric absorptive microsampling device is used to collect an exact amount of sample and from that same tip an electrospray can be directed into a mass spectrometer. We demonstrate here that, although with significant matrix effects, quantitation of penicillin G, a common antimicrobial, is, possible in plasma and in urine, with essentially no sample preparation.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2017. Vol. 89, no 21, p. 11592-11597
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-82314DOI: 10.1021/acs.analchem.7b02957ISI: 000414887000061PubMedID: 29028329Scopus ID: 2-s2.0-85053129729OAI: oai:DiVA.org:oru-82314DiVA, id: diva2:1434196
Note

Funding Agency:

Ministry of Education and Research, Estonia

Available from: 2020-06-02 Created: 2020-06-02 Last updated: 2020-08-18Bibliographically approved

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Aro, Rudolf

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Hecht, MaxEvard, HannoAro, RudolfLohmus, RynnoLeito, IvoKipper, Karin
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