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Functional and structural change in diabetic eyes. Interim results from an ongoing longitudinal prospective study
Lund Univ, Malmö, Sweden; Cty Hosp Värmland, Karlstad, Sweden.ORCID iD: 0000-0003-4273-0741
Lund Univ, Malmö, Sweden.
Lund Univ, Malmö, Sweden.
2013 (English)In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 91, no 7, p. 672-677Article in journal (Refereed) Published
Abstract [en]

Purpose: To presents results after 18months of follow-up of a longitudinal study aiming at exploring the correlation between diabetic retinal vascular lesions and functional change.

Methods: Patients were consecutively recruited from attendees to the screening program for diabetic retinopathy. Subjects are followed every sixth month for the first 3years and thereafter annually up to 5years. Progression of diabetic retinopathy is evaluated using the Early Treatment Diabetic Retinopathy Study (ETDRS) scale and improvement/deterioration in visual fields by predefined significance limits for change.

Results: Of 81 subjects, with no/mild/moderate diabetic retinopathy included, 76 have passed the 18-month visit. At that time, retinal progression by two steps according to the ETDRS scale had occurred in two subjects. Visual acuity was -0.14 logMAR and had decreased with two letters (0.04 logMAR) (p<0.001) from baseline. The global visual field index mean deviation was almost unchanged with a negligible improvement of 0.03dB (p=0.79). In 21 subjects, repeated significant deterioration was seen in 10% of all points tested in the field, while almost no improved points were noted. The two subjects with retinal progression were not among those 21 with indication of perimetric progression.

Conclusions: This is, to our knowledge, the first longitudinal study evaluating change of visual fields in a representative diabetic cohort with no or mild/moderate retinopathy. In this interim report, we demonstrate deteriorated perimetric sensitivity in subjects already at 18months of follow-up. The results will have implications for evaluating change in visual function in future clinical trials.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2013. Vol. 91, no 7, p. 672-677
Keywords [en]
Diabetic retinopathy, longitudinal study design, perimetry, visual function
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:oru:diva-82329DOI: 10.1111/j.1755-3768.2012.02508.xISI: 000328323000032PubMedID: 23025256Scopus ID: 2-s2.0-84885956398OAI: oai:DiVA.org:oru-82329DiVA, id: diva2:1434420
Available from: 2020-06-03 Created: 2020-06-03 Last updated: 2020-06-03Bibliographically approved

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