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Anti-inflammatory Properties of Doxycycline and Minocycline in Experimental Models: An in Vivo and in Vitro Comparative Study
Faculty of Medicine of Juazeiro de Norte, Juazeiro do Norte, Brazil.
Faculty of Medicine of Juazeiro de Norte, Juazeiro do Norte, Brazil.
Faculty of Medicine of Juazeiro de Norte, Juazeiro do Norte, Brazil.
Faculty of Medicine of Juazeiro de Norte, Juazeiro do Norte, Brazil.
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2011 (English)In: InflammoPharmacology, ISSN 0925-4692, E-ISSN 1568-5608, Vol. 19, no 2, p. 99-110Article in journal (Refereed) Published
Abstract [en]

Aims and methods: Minocycline (Mino) and doxycycline (Dox) are second generation tetracyclines known to present several other effects, which are independent from their antimicrobial activities. We studied in a comparative way the anti-inflammatory effects of Mino and Dox, on acute models of peripheral inflammation in rodents (formalin test and peritonitis in mice, and carrageenan-induced paw oedema in rats). Immunohistochemical assays for TNF-alpha and iNOS in rat paws of carrageenan-induced oedema were also carried out as well as in vitro assays for myeloperoxidase (MPO) and lactate dehydrogenase (LDH). Furthermore, antioxidant activities were evaluated by the DPPH assay.

Results: In the formalin test although Mino and Dox (1, 5, 10 and 25 mg/kg, i.p.) inhibited the first phase, they acted predominantly on the second phase of the test, where inhibition of the licking time close to 80% were observed. Mino and Dox were very efficacious in reducing the carrageenan-induced paw oedema in rats (10, 25 and 50 mg/kg, i.p.) and carrageenan-induced leucocyte migration (1 and 5 mg/kg, i.p.) to mice peritoneal cavities. Besides, they also significantly inhibited MPO and LDH releases at doses ranging from 0.001 to 1 μg/ml. Thus, in general, the anti-inflammatory activity of Dox was higher as compared to that of Mino, although the radical scavenging activity of Mino was of a magnitude 10 times higher.

Conclusions: Our data indicate that anti-inflammatory and antioxidant effects, involve the inhibition of iNOS and TNF-alpha, among other properties, and these encourage clinical studies of these compounds for new therapeutic applications, especially those were inflammation plays a role.

Place, publisher, year, edition, pages
Springer, 2011. Vol. 19, no 2, p. 99-110
Keywords [en]
Minocycline, Doxycycline, Inflammation, Cytokines, Antioxidant effect
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:oru:diva-82881DOI: 10.1007/s10787-011-0077-5Scopus ID: 2-s2.0-79958205912OAI: oai:DiVA.org:oru-82881DiVA, id: diva2:1438074
Note

Funding Agency:

Brazilian National Research Council (CNPq)

Available from: 2020-06-10 Created: 2020-06-10 Last updated: 2022-02-09Bibliographically approved

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