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EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals
The University of Texas at Austin, Austin, USA.
National Institute of Environmental Health Sciences, Research Triangle Park, USA.
National Institute of Environmental Health Sciences, Research Triangle Park, USA.
University of Illinois at Urbana- Champaign, Urbana, USA.
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2015 (English)In: Endocrine reviews, ISSN 0163-769X, E-ISSN 1945-7189, Vol. 36, no 6, p. E1-E150Article, review/survey (Refereed) Published
Abstract [en]

The Endocrine Society's first Scientific Statement in 2009 provided a wake-up call to the scientific community about how environmental endocrine-disrupting chemicals (EDCs) affect health and disease. Five years later, a substantially larger body of literature has solidified our understanding of plausible mechanisms underlying EDC actions and how exposures in animals and humans-especially during development-may lay the foundations for disease later in life. At this point in history, we have much stronger knowledge about how EDCs alter gene-environment interactions via physiological, cellular, molecular, and epigenetic changes, thereby producing effects in exposed individuals as well as their descendants. Causal links between exposure and manifestation of disease are substantiated by experimental animal models and are consistent with correlative epidemiological data in humans. There are several caveats because differences in how experimental animal work is conducted can lead to difficulties in drawing broad conclusions, and we must continue to be cautious about inferring causality in humans. In this second Scientific Statement, we reviewed the literature on a subset of topics for which the translational evidence is strongest: 1) obesity and diabetes; 2) female reproduction; 3) male reproduction; 4) hormone-sensitive cancers in females; 5) prostate; 6) thyroid; and 7) neurodevelopment and neuroendocrine systems. Our inclusion criteria for studies were those conducted predominantly in the past 5 years deemed to be of high quality based on appropriate negative and positive control groups or populations, adequate sample size and experimental design, and mammalian animal studies with exposure levels in a range that was relevant to humans. We also focused on studies using the developmental origins of health and disease model. No report was excluded based on a positive or negative effect of the EDC exposure. The bulk of the results across the board strengthen the evidence for endocrine health-related actions of EDCs. Based on this much more complete understanding of the endocrine principles by which EDCs act, including nonmonotonic dose-responses, low-dose effects, and developmental vulnerability, these findings can be much better translated to human health. Armed with this information, researchers, physicians, and other healthcare providers can guide regulators and policymakers as they make responsible decisions.

Place, publisher, year, edition, pages
Oxford University Press, 2015. Vol. 36, no 6, p. E1-E150
National Category
Occupational Health and Environmental Health
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-83764DOI: 10.1210/er.2015-1010ISI: 000368277700001PubMedID: 26544531Scopus ID: 2-s2.0-84983150574OAI: oai:DiVA.org:oru-83764DiVA, id: diva2:1448171
Note

Funding Agency:

United States Department of Health & Human Services, National Institutes of Health (NIH) - USA

Spanish Government

Generalitat Valenciana

Academy of Finland

EU FP7 Environment and Quality of Life

Sigrid Juselius Foundation

Turku University Hospital Special Research Fund 

Available from: 2020-06-26 Created: 2020-06-26 Last updated: 2022-12-30Bibliographically approved

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Zoeller, R. Thomas

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