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Morphology vs morphokinetics: a retrospective comparison of inter-observer and intra-observer agreement between embryologists on blastocysts with known implantation outcome
Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0002-7954-0696
Örebro University Hospital, Örebro, Sweden.
2018 (English)In: Jornal Brasileiro de Reproducao Assistida, ISSN 1517-5693, Vol. 22, no 3, p. 228-237Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Our primary aim was to compare the morphology and morphokinetics on inter- and intra-observer agreement for blastocyst with known implantation outcome. Our secondary aim was to validate the morphokinetic parameters' ability to predict pregnancy using a previous published selection algorithm, and to compare this to standard morphology assessments.

METHODS: Two embryologists made independent blinded annotations on two occasions using time-lapse images and morphology evaluations using the Gardner Schoolcraft criteria of 99 blastocysts with known implantation outcome. Inter- and intra-observer agreement was calculated and compared using the two methods. The embryos were grouped based on their morphological score, and on their morphokinetic class using a previous published selection algorithm. The implantation rates for each group was calculated and compared.

RESULTS: There was moderate agreement for morphology, with agreement on the same embryo score in 55 of 99 cases. The highest agreement rate was found for expansion grade, followed by trophectoderm and inner cell mass. Correlation with pregnancy was inconclusive. For morphokinetics, almost perfect agreement was found for early and late embryo development events, and strong agreement for day-2 and day-3 events. When applying the selection algorithm, the embryo distributions were uneven, and correlation to pregnancy was inconclusive.

CONCLUSIONS: Time-lapse annotation is consistent and accurate, but our external validation of a previously published selection algorithm was unsuccessful.

Place, publisher, year, edition, pages
2018. Vol. 22, no 3, p. 228-237
Keywords [en]
IVF, embryo development, morphokinetics, observer agreement, time lapse
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:oru:diva-84138DOI: 10.5935/1518-0557.20180042ISI: 000442241700012PubMedID: 29912521Scopus ID: 2-s2.0-85052812580OAI: oai:DiVA.org:oru-84138DiVA, id: diva2:1450139
Available from: 2020-07-01 Created: 2020-07-01 Last updated: 2021-05-10Bibliographically approved

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Adolfsson, Emma

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CiteExportLink to record
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