Higher body mass index at ages 16 to 20 years is associated with increased risk of a multiple sclerosis diagnosis in subsequent adulthood among menShow others and affiliations
2021 (English)In: Multiple Sclerosis Journal, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 27, no 1, p. 147-150Article in journal (Refereed) Published
Abstract [en]
Background: Evidence for the association between body mass index (BMI) and multiple sclerosis (MS) among men remains mixed.
Objective and methods: Swedish military conscription and other registers identified MS after age of 20 years and BMI at ages 16-20 years (N = 744,548).
Results: Each unit (kg/m(2)) BMI increase was associated with greater MS risk (hazard ratio and 95% confidence interval = 1.034, 1.016-1.053), independent of physical fitness (1.021, 1.001-1.042). Categorised, overweight and obesity were associated with statistically significant raised MS risk compared to normal weight, but not after adjustment for physical fitness.
Conclusion: MS risk rises with increasing BMI, across the entire BMI range.
Place, publisher, year, edition, pages
Sage Publications, 2021. Vol. 27, no 1, p. 147-150
Keywords [en]
Obesity, underweight, body mass index, multiple sclerosis, men, adolescence
National Category
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-84506DOI: 10.1177/1352458520928061ISI: 000539062700001PubMedID: 32507076Scopus ID: 2-s2.0-85086112570OAI: oai:DiVA.org:oru-84506DiVA, id: diva2:1457889
Funder
Swedish Research CouncilThe Swedish Brain Foundation
Note
Funding Agencies:
Economic & Social Research Council (ESRC) RES-596-28-0001 ES/JO19119/1
Nyckelfonden
2020-08-132020-08-132022-10-17Bibliographically approved