Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipidsRostock University Medical Center, Department of Hematology, Oncology and Palliative Medicine, Rostock, Germany.
Rostock University Medical Center, Department of Hematology, Oncology and Palliative Medicine, Rostock, Germany.
Rostock University Medical Center, Department of Hematology, Oncology and Palliative Medicine, Rostock, Germany.
Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Department of Measurement and Information Systems, Budapest University of Technology and Economics, Budapest, Hungary; Abiomics Europe Ltd., Budapest, Hungary.
Institute of Computer Science, BIIT research group, University of Tartu, Tartu, Estonia.
Institute of Computer Science, BIIT research group, University of Tartu, Tartu, Estonia.
Max-Planck Institute for Molecular Biomedicine, Münster, Germany.
University of Rostock, Institute for Philosophy, Rostock, Germany.
University Medicine Greifswald, Clinic and Polyclinic for Psychiatry and Psychotherapy, Greifswald, Germany.
Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research, IBIMA, Rostock, Germany; University Medicine Greifswald, Institute for Community Medicine, Greifswald, Germany.
Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research, IBIMA, Rostock, Germany.
Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research, IBIMA, Rostock, Germany.
KU Leuven, Department of Biology, Leuven, Belgium.
KU Leuven, Department of Biology, Leuven, Belgium.
KU Leuven, Department of Biology, Leuven, Belgium.
Rostock University Medical Center, Institute for Biostatistics and Informatics in Medicine and Aging Research, IBIMA, Rostock, Germany.
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2020 (English)In: Aging, E-ISSN 1945-4589, Vol. 12, no 13, p. 12534-12581Article, review/survey (Refereed) Published
Abstract [en]
The molecular basis of aging and of aging-associated diseases is being unraveled at an increasing pace. An extended healthspan, and not merely an extension of lifespan, has become the aim of medical practice. Here, we define health based on the absence of diseases and dysfunctions. Based on an extensive review of the literature, in particular for humans and C. elegans, we compile a list of features of health and of the genes associated with them. These genes may or may not be associated with survival/lifespan. In turn, survival/lifespan genes that are not known to be directly associated with health are not considered. Clusters of these genes based on molecular interaction data give rise to maps of healthspan pathways for humans and for C. elegans. Overlaying healthspan-related gene expression data onto the healthspan pathway maps, we observe the downregulation of (pro-inflammatory) Notch signaling in humans and of proliferation in C. elegans. We identify transcription, proliferation/biosynthesis and lipids as a common theme on the annotation level, and proliferation-related kinases on the gene/protein level. Our literature-based data corpus, including visualization, should be seen as a pilot investigation of the molecular underpinnings of health in two different species.
Place, publisher, year, edition, pages
Impact Journals LLC , 2020. Vol. 12, no 13, p. 12534-12581
Keywords [en]
Gene expression analysis, network biology analysis
National Category
Immunology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-84700DOI: 10.18632/aging.103514ISI: 000573897700008PubMedID: 32634117Scopus ID: 2-s2.0-85088494939OAI: oai:DiVA.org:oru-84700DiVA, id: diva2:1461108
Funder
EU, Horizon 2020, 633589
Note
Funding Agencies:
Fonds de la Recherche en Sante du Quebec
Estonian Research Agency grant IUT34-4
FWO 11A5420N
BME NC TKP2020 grant of NKFIH Hungary
BME-Biotechnology FIKP grant of EMMI (BME FIKP-BIO)
Orszagos Tudomanyos Kutatasi Alapprogramok (OTKA) K119866
2020-08-262020-08-262024-07-04Bibliographically approved