Neural processing of socioemotional content in conduct-disordered offenders with limited prosocial emotionsShow others and affiliations
2021 (English)In: Progress in Neuro-psychopharmacology and Biological Psychiatry, ISSN 0278-5846, E-ISSN 1878-4216, Vol. 105, article id 110045Article in journal (Refereed) Published
Abstract [en]
BACKGROUND: Reflecting evidence on Callous-Unemotional (CU) traits (e.g., lack of empathy and guilt, shallow affect), the DSM-5 added a categorical CU-based specifier for Conduct Disorder (CD), labeled 'with Limited Prosocial Emotions' (LPE). Theory and prior work suggest that CD youths with and without LPE will likely differ in neural processing of negative socioemotional content. This proposition, however, is mainly derived from studies employing related, yet distinct, operationalizations of CU traits (e.g., dimensional measure/median split/top quartile), thus precluding direct examination of LPE-specific neurocognitive deficits.
METHODS: Employing a DSM-5 informed LPE proxy, neural processing of recognizing and resonating negative socioemotional content (angry and fearful faces) was therefore examined here among CD offenders with LPE (CD/LPE+; N = 19), relative to CD offenders without LPE (CD/LPE-; N = 31) and healthy controls (HC; N = 31).
RESULTS: Relative to HC and CD/LPE- youths and according to a linearly increasing trend (CD/LPE- < HC < CD/LPE+), CD/LPE+ youths exhibited hyperactivity within dorsolateral, dorsomedial, and ventromedial prefrontal regions during both emotion recognition and resonance. During emotion resonance, CD/LPE+ youths additionally showed increased activity within the posterior cingulate and precuneal cortices in comparison to HC and CD/LPE- youths, which again followed a linearly increasing trend (CD/LPE- < HC < CD/LPE+). These effects moreover seemed specific to the LPE specifier, when compared to a commonly employed method for CU-based grouping in CD (i.e., median split on CU scores).
CONCLUSIONS: These data cautiously suggest that CD/LPE+ youths may exhibit an over-reliance on cortical neurocognitive systems when explicitly processing negative socioemotional information, which could have adverse downstream effects on relevant socioemotional functions. The findings thus seem to provide novel, yet preliminary, clues on the neurocognitive profile of CD/LPE+, and additionally highlight the potential scientific utility of the LPE specifier.
Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 105, article id 110045
Keywords [en]
Brain function, CU traits, Conduct disorder, Limited prosocial emotions, Psychopathy, Socioemotional processing
National Category
Psychology
Identifiers
URN: urn:nbn:se:oru:diva-84733DOI: 10.1016/j.pnpbp.2020.110045ISI: 000600415100031PubMedID: 32735912Scopus ID: 2-s2.0-85090575914OAI: oai:DiVA.org:oru-84733DiVA, id: diva2:1461853
Note
Funding Agencies:
Netherlands Organization for Scientific Research - National Initiative Brain and Cognition (NWO-NIHC) 056-230-11
Örebro University
Leiden Institute Brain and Cognition
2020-08-272020-08-272021-01-15Bibliographically approved