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Association between mental disorders and somatic conditions: protocol for an umbrella review
Centre for Innovation in Mental Health (CIMH), School of Psychology, University of Southampton, Southampton, UK; Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK; Solent NHS Trust, Southampton, UK; Division of Psychiatry and Applied Psychology, School of Medicine, University of Nottingham, Nottingham, UK; National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, NIHR MindTech MedTech Co-operative, Nottingham, UK; Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine, New York, New York, USA.
Neuroscience Department, Psychiatry Unit, Padua Neuroscience Center, University of Padua, Padua, Italy; Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Mind-Brain Group. Institute for Culture and Society, University of Navarra, Pamplona, Spain.
Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK; Oxford Health NHS Foundation Trust, Warneford Hospital, Oxford, UK.
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2020 (English)In: Evidence-Based Mental Health, ISSN 1362-0347, E-ISSN 1468-960X, Vol. 23, no 4, p. 135-139Article, review/survey (Refereed) Published
Abstract [en]

INTRODUCTION: Although several systematic reviews (SRs)/meta-analyses (MAs) on the association between specific mental disorders and specific somatic conditions are available, an overarching evidence synthesis across mental disorders and somatic conditions is currently lacking. We will conduct an umbrella review of SRs/MAs to test: 1) the strength of the association between individual mental disorders and individual somatic conditions in children/adolescents and adults; 2) to which extent associations are specific to individual mental and somatic conditions .

METHODS AND ANALYSIS: We will search a broad set of electronic databases and contact study authors. We will include SRs with MA or SRs reporting the effect size from individual studies on the association between a number of somatic and mental conditions (as per the International Classification of Diseases, 11th Revision). We will follow an algorithm to select only one SR or MA when more than one are available on the same association. We will rate the quality of included SRs/MAs using the AMSTAR-2 tool. We will assess to which extent mental disorders are selectively associated with specific somatic conditions or if there are transdiagnostic, across-spectra or diagnostic spectrum-specific associations between mental disorders and somatic conditions based on the Transparent, Reporting, Appraising, Numerating, Showing (TRANSD) recommendations.

DISCUSSION: The present umbrella review will shed light on the association between mental health disorders and somatic conditions, providing useful data for the care of patients with mental health disorders, in particular for early detection and intervention. This work might also add insight to the pathophysiology of mental health conditions, and contribute to the current debate on the value of a transdiagnostic approach in psychiatry.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2020. Vol. 23, no 4, p. 135-139
Keywords [en]
Adult psychiatry, child & adolescent psychiatry
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-85731DOI: 10.1136/ebmental-2020-300158ISI: 000584955400004PubMedID: 32900790Scopus ID: 2-s2.0-85094933177OAI: oai:DiVA.org:oru-85731DiVA, id: diva2:1470017
Note

Funding Agencies:

Spanish Ministry of Science, Innovation and Universities CAS19/00249NIHR

Oxford Cognitive Health Clinical Research Facility  

NIHR Research Professorship RP-2017-08-ST2-006

National Institute for Health Research (NIHR)

Thames Valley Applied Research Collaboration  

NIHR Oxford Health Biomedical Research Centre  IS-BRC-1215-20005

Available from: 2020-09-23 Created: 2020-09-23 Last updated: 2023-06-20Bibliographically approved

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