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The association between body dysmorphic symptoms and suicidality among adolescents and young adults: a genetically informative study
King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK; National and Specialist OCD and Related Disorders Clinic for Young People, South London, UK; Maudsley NHS Foundation Trust, London, UK.
Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.
King's College London, MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, London, UK.
Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden; Stockholm .
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2022 (English)In: Psychological Medicine, ISSN 0033-2917, E-ISSN 1469-8978, Vol. 52, no 7, p. 1268-1276Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Previous research indicates that body dysmorphic disorder (BDD) is associated with risk of suicidality. However, studies have relied on small and/or specialist samples and largely focussed on adults, despite these difficulties commonly emerging in youth. Furthermore, the aetiology of the relationship remains unknown.

METHODS: Two independent twin samples were identified through the Child and Adolescent Twin Study in Sweden, at ages 18 (N = 6027) and 24 (N = 3454). Participants completed a self-report measure of BDD symptom severity. Young people and parents completed items assessing suicidal ideation/behaviours. Logistic regression models tested the association of suicidality outcomes with: (a) probable BDD, classified using an empirically derived cut-off; and (b) continuous scores of BDD symptoms. Bivariate genetic models examined the aetiology of the association between BDD symptoms and suicidality at both ages.

RESULTS: Suicidal ideation and behaviours were common among those with probable BDD at both ages. BDD symptoms, measured continuously, were linked with all aspects of suicidality, and associations generally remained significant after adjusting for depressive and anxiety symptoms. Genetic factors accounted for most of the covariance between BDD symptoms and suicidality (72.9 and 77.7% at ages 18 and 24, respectively), but with significant non-shared environmental influences (27.1 and 22.3% at ages 18 and 24, respectively).

CONCLUSIONS: BDD symptoms are associated with a substantial risk of suicidal ideation and behaviours in late adolescence and early adulthood. This relationship is largely explained by common genetic liability, but non-shared environmental effects are also significant and could provide opportunities for prevention among those at high-risk.

Place, publisher, year, edition, pages
Cambridge University Press, 2022. Vol. 52, no 7, p. 1268-1276
Keywords [en]
Adolescence, body dysmorphic disorder, genetics, suicidal ideation, suicide attempts, twin design
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-85868DOI: 10.1017/S0033291720002998ISI: 000803839800008PubMedID: 32940195Scopus ID: 2-s2.0-85092253116OAI: oai:DiVA.org:oru-85868DiVA, id: diva2:1470106
Funder
Swedish Research Council, 2017-00641 ALFGBG-776031 2017-02552 2016-01989Forte, Swedish Research Council for Health, Working Life and Welfare, 2012-1678 2014-0834
Note

Funding agencies:

UK Research & Innovation (UKRI)

Medical Research Council UK (MRC) MR/N001400/1 MR/M021475/1  

General Electric

Available from: 2020-09-23 Created: 2020-09-23 Last updated: 2022-06-21Bibliographically approved

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Larsson, Henrik

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