To Örebro University

oru.seÖrebro University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Risk of Skin Disorders in Patients with Celiac Disease: A Population-Based Cohort Study
Celiac Disease Center, Department of Medicine, Columbia University Medical Center, New York NY, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York NY, USA.
Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Show others and affiliations
2021 (English)In: The Journal of American Academy of Dermatology, ISSN 0190-9622, E-ISSN 1097-6787, Vol. 85, no 6, p. 1456-1464Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND AIMS: Although dermatitis herpetiformis is closely associated with celiac disease (CD), data on the relationship between CD and other dermatologic disorders have been mixed. We aimed to quantify the risk of skin disorders in patients after CD diagnosis in a population-based setting.

METHODS: Using data from all 28 pathology departments in Sweden 1969-2016, we identified patients with CD. Each patient was matched by age, sex, calendar year, and geographic region to up to 5 population controls. We calculated the risk of any skin disease and specific skin diseases using Cox proportional hazards.

RESULTS: We identified 43,300 patients with CD and 198,532 matched controls. After a median follow-up time of 11.4 years, the incidences of skin disease in CD patients and controls were 22.6 and 14.8 per 1000 person-years respectively (HR=1.55; 95%CI 1.51-1.58). Increased risks were present for eczema (HR=1.67; 95%CI 1.56-1.79), psoriasis (HR=1.55; 95%CI 1.43-1.68), urticaria (HR=1.52; 95% CI 1.42-1.64), vitiligo (HR=1.90; 95%CI 1.52-2.39), acne (HR=1.39; 95%CI 1.29-1.50), and alopecia areata (HR=1.78; 95%CI 1.43-2.20).

CONCLUSIONS: Compared to the general population, patients with CD are at increased risk of multiple common skin disorders, a risk that persists in the long-term.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 85, no 6, p. 1456-1464
Keywords [en]
Celiac disease, dermatology, epidemiology
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:oru:diva-87226DOI: 10.1016/j.jaad.2020.10.079ISI: 000723647700059PubMedID: 33144153Scopus ID: 2-s2.0-85117250763OAI: oai:DiVA.org:oru-87226DiVA, id: diva2:1499077
Funder
The Karolinska Institutet's Research FoundationSwedish Research CouncilEuropean Commission
Note

Funding agencies:

Janssen Corporation

Celiac Disease Foundation Young Investigator Research Grant Award

Louis and Gloria Flanzer Philanthropic Trust

Available from: 2020-11-06 Created: 2020-11-06 Last updated: 2023-12-08Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Ludvigsson, Jonas F.

Search in DiVA

By author/editor
Ludvigsson, Jonas F.
By organisation
School of Medical SciencesÖrebro University Hospital
In the same journal
The Journal of American Academy of Dermatology
Dermatology and Venereal Diseases

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 82 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf