Risk of Skin Disorders in Patients with Celiac Disease: A Population-Based Cohort StudyShow others and affiliations
2021 (English)In: The Journal of American Academy of Dermatology, ISSN 0190-9622, E-ISSN 1097-6787, Vol. 85, no 6, p. 1456-1464Article in journal (Refereed) Published
Abstract [en]
BACKGROUND AND AIMS: Although dermatitis herpetiformis is closely associated with celiac disease (CD), data on the relationship between CD and other dermatologic disorders have been mixed. We aimed to quantify the risk of skin disorders in patients after CD diagnosis in a population-based setting.
METHODS: Using data from all 28 pathology departments in Sweden 1969-2016, we identified patients with CD. Each patient was matched by age, sex, calendar year, and geographic region to up to 5 population controls. We calculated the risk of any skin disease and specific skin diseases using Cox proportional hazards.
RESULTS: We identified 43,300 patients with CD and 198,532 matched controls. After a median follow-up time of 11.4 years, the incidences of skin disease in CD patients and controls were 22.6 and 14.8 per 1000 person-years respectively (HR=1.55; 95%CI 1.51-1.58). Increased risks were present for eczema (HR=1.67; 95%CI 1.56-1.79), psoriasis (HR=1.55; 95%CI 1.43-1.68), urticaria (HR=1.52; 95% CI 1.42-1.64), vitiligo (HR=1.90; 95%CI 1.52-2.39), acne (HR=1.39; 95%CI 1.29-1.50), and alopecia areata (HR=1.78; 95%CI 1.43-2.20).
CONCLUSIONS: Compared to the general population, patients with CD are at increased risk of multiple common skin disorders, a risk that persists in the long-term.
Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 85, no 6, p. 1456-1464
Keywords [en]
Celiac disease, dermatology, epidemiology
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:oru:diva-87226DOI: 10.1016/j.jaad.2020.10.079ISI: 000723647700059PubMedID: 33144153Scopus ID: 2-s2.0-85117250763OAI: oai:DiVA.org:oru-87226DiVA, id: diva2:1499077
Funder
The Karolinska Institutet's Research FoundationSwedish Research CouncilEuropean Commission
Note
Funding agencies:
Janssen Corporation
Celiac Disease Foundation Young Investigator Research Grant Award
Louis and Gloria Flanzer Philanthropic Trust
2020-11-062020-11-062023-12-08Bibliographically approved