Matrix metalloproteinase (MMP) -1, -2, -3 and -9 promoter polymorphisms in colorectal cancer
2006 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 26, no 1B, p. 791-795, article id 16739355Article in journal (Refereed) Published
Abstract [en]
Background: Matrix metalloproteinases (MMPs) are a group of matrix-degrading proteins implicated in several pathological processes, e.g., invasion and metastasis in malignant diseases such as colorectal cancer (CRC).
Materials and methods: One hundred and twenty-seven CRC patients and 208 controls were genotyped for MMP-1, -2, -3 and -9 promoter polymorphisms. The genotyping was performed with PCR/primer-extension/DHPLC or PCR/RFLP.
Results: The MMP-1 2G allele was significantly associated with CRC (p=0.037). No significant association between CRC and MMP-2, -3 or -9 polymorphisms was evident. The analysis of polymorphisms in the clinicopathological subgroups displayed no significant associations.
Conclusion: The MMP-1 promoter polymorphism seems to affect the susceptibility to CRC, while MMP-2, -3 and -9 polymorphisms appear less likely to have any impact on CRC.
Place, publisher, year, edition, pages
International Institute of Anticancer Research , 2006. Vol. 26, no 1B, p. 791-795, article id 16739355
Keywords [en]
MMP-1, MMP-2, MMP-3, MMP-9, promoter, polymorphism, colorectal cance
National Category
Cancer and Oncology Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-87253ISI: 000235104100052PubMedID: 16739355OAI: oai:DiVA.org:oru-87253DiVA, id: diva2:1499197
2020-11-072020-11-072022-08-05Bibliographically approved