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Matrix metalloproteinase (MMP) -1, -2, -3 and -9 promoter polymorphisms in colorectal cancer
Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping, Sweden.
Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping, Sweden.
Örebro University, School of Medical Sciences. Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping, Sweden.ORCID iD: 0000-0002-9826-0462
2006 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 26, no 1B, p. 791-795, article id 16739355Article in journal (Refereed) Published
Abstract [en]

Background: Matrix metalloproteinases (MMPs) are a group of matrix-degrading proteins implicated in several pathological processes, e.g., invasion and metastasis in malignant diseases such as colorectal cancer (CRC).

Materials and methods: One hundred and twenty-seven CRC patients and 208 controls were genotyped for MMP-1, -2, -3 and -9 promoter polymorphisms. The genotyping was performed with PCR/primer-extension/DHPLC or PCR/RFLP.

Results: The MMP-1 2G allele was significantly associated with CRC (p=0.037). No significant association between CRC and MMP-2, -3 or -9 polymorphisms was evident. The analysis of polymorphisms in the clinicopathological subgroups displayed no significant associations.

Conclusion: The MMP-1 promoter polymorphism seems to affect the susceptibility to CRC, while MMP-2, -3 and -9 polymorphisms appear less likely to have any impact on CRC.

Place, publisher, year, edition, pages
International Institute of Anticancer Research , 2006. Vol. 26, no 1B, p. 791-795, article id 16739355
Keywords [en]
MMP-1, MMP-2, MMP-3, MMP-9, promoter, polymorphism, colorectal cance
National Category
Cancer and Oncology Cell and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-87253ISI: 000235104100052PubMedID: 16739355OAI: oai:DiVA.org:oru-87253DiVA, id: diva2:1499197
Available from: 2020-11-07 Created: 2020-11-07 Last updated: 2022-08-05Bibliographically approved

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PubMedMatrix Metalloproteinase (MMP) -1, -2, -3 and -9 Promoter Polymorphisms in Colorectal Cancer

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Fransén, Karin

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