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β-Amyloid binding in elderly subjects with declining or stable episodic memory function measured with PET and [11C]AZD2184
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Karolinska Institutet, Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska University Hospital, Stockholm, Sweden.
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Aging Research Center (ARC), Karolinska Institute and Stockholm University.ORCID iD: 0000-0001-9143-3730
Department of Radiation Sciences (Diagnostic Radiology), Umeå University, Umeå, Sweden.
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2015 (English)In: European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, E-ISSN 1619-7089, Vol. 42, no 10, p. 1507-1511Article in journal (Refereed) Published
Abstract [en]

Purpose: Cognitive decline has been suggested as an early marker for later onset of Alzheimer's disease. We therefore explored the relationship between decline in episodic memory and β-amyloid using positron emission tomography (PET) and [11C]AZD2184, a radioligand with potential to detect low levels of amyloid deposits.

Methods: Healthy elderly subjects with declining (n = 10) or stable (n = 10) episodic memory over 15 years were recruited from the population-based Betula study and examined with PET. Brain radioactivity was measured after intravenous administration of [11C]AZD2184 The binding potential BP ND was calculated using linear graphical analysis with the cerebellum as reference region.

Results: The binding of [11C]AZD2184 in total grey matter was generally low in the declining group, whereas some binding could be observed in the stable group. Mean BP ND was significantly higher in the stable group compared to the declining group (p = 0.019). An observation was that the three subjects with the highest BPND were ApoE ε4 allele carriers.

Conclusions: We conclude that cognitive decline in the general population does not seem to stand by itself as an early predictor for amyloid deposits.

Place, publisher, year, edition, pages
Springer, 2015. Vol. 42, no 10, p. 1507-1511
Keywords [en]
aging, amyloid, cognitive decline, positron emission tomography
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:oru:diva-87564DOI: 10.1007/s00259-015-3103-9ISI: 000358735100003PubMedID: 26115835Scopus ID: 2-s2.0-84938415931OAI: oai:DiVA.org:oru-87564DiVA, id: diva2:1503426
Funder
Swedish Research Council, K2012-61X-09114AstraZeneca
Note

Funding Agencies:

Stockholm Brain Institute

Wallenberg Scholar Grant

Available from: 2020-11-24 Created: 2020-11-24 Last updated: 2020-11-30Bibliographically approved

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Persson, JonasNyberg, Lars

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