Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in AgingShow others and affiliations
2015 (English)In: Neuropsychology Review, ISSN 1040-7308, E-ISSN 1573-6660, Vol. 25, no 1, p. 47-62Article, review/survey (Refereed) Published
Abstract [en]
Increasing evidence from cross-sectional and longitudinal molecular-genetic studies suggests that effects of common genetic variations on cognitive functioning increase with aging. We review the influence of candidate genes on brain functioning in old age, focusing on four genetic variations that have been extensively investigated: APOE, BDNF, COMT, and KIBRA. Similar to the behavioral evidence, there are reports from age-comparative studies documenting stronger genetic effects on measures of brain functioning in older adults compared to younger adults. This pattern suggests disproportionate impairments of neural processing among older individuals carrying disadvantageous genotypes. We discuss various factors, including gene-gene interactions, study population characteristics, lifestyle factors, and diseases, that need to be considered in future studies and may help understand inconsistent findings in the extant literature.
Place, publisher, year, edition, pages
Springer, 2015. Vol. 25, no 1, p. 47-62
Keywords [en]
Aging, Functional brain imaging, Cognition, Genetics, APOE, BDNF, COMT, KIBRA
National Category
Psychology Neurology
Identifiers
URN: urn:nbn:se:oru:diva-87567DOI: 10.1007/s11065-015-9279-8ISI: 000352822500004PubMedID: 25666727Scopus ID: 2-s2.0-84939989914OAI: oai:DiVA.org:oru-87567DiVA, id: diva2:1503519
Funder
Swedish Research CouncilForte, Swedish Research Council for Health, Working Life and Welfare
Note
Funding Agency:
Swedish Brain Power, an Alexander von Humboldt Research Award
2020-11-242020-11-242020-11-30Bibliographically approved