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Clinical characteristics and validation of diagnosis in individuals with Hirschsprung disease and inflammatory bowel disease
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Department of Surgery, Danderyd Hospital & Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, SE, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Celiac Disease Center, Columbia University College of Physicians and Surgeons, New York, NY, USA.ORCID iD: 0000-0003-1024-5602
Department of Women's and Children's Health, Unit of Pediatric Surgery, Karolinska University Hospital and Pediatric Research Unit, Karolinska Institutet, Stockholm, Sweden.
2021 (English)In: Journal of Pediatric Surgery, ISSN 0022-3468, E-ISSN 1531-5037, Vol. 56, no 10, p. 1799-1802Article in journal (Refereed) Published
Abstract [en]

BACKGROUND/PURPOSE: Hirschsprung disease has previously been reported to be associated with inflammatory bowel disease (IBD). The aim was to clinically confirm the diagnosis and to describe characteristics among individuals with both conditions in a national populationbased cohort.

METHODS: Nationwide, population-based cohort study, including all individuals with a Hirschsprung disease diagnosis and an IBD diagnosis registered between 1964 and 2016, in which clinical data were collected from the medical records of 18 validated cases with both Hirschsprung disease and IBD. The medical record of each individual in the study cohort was reviewed for age at IBD diagnosis, type of aganglionosis, type of surgical treatment, subtype of IBD, and treatment for IBD.

RESULTS: Median age at follow up was 34 years (range 19-66), and 3 of 18 indivduals (17%) were females. Median age at first diagnosis of IBD was 21 years (range 10-46). Six patients had ulcerative colitis, ten had Crohn's disease and two had unclassified IBD. Most of the patients had pharmacological treatment for IBD and 5 (28%) individuals had surgical treatment.

CONCLUSION: Hirschsprung disease and IBD was clinically confirmed in 18 cases. Age at IBD onset and subtype of IBD is similar to IBD patients without Hirschsprung disease. Five individuals had undergone surgical treatment for IBD.

Place, publisher, year, edition, pages
Saunders Elsevier, 2021. Vol. 56, no 10, p. 1799-1802
Keywords [en]
Crohn's disease, Epidemiology, Hirschsprung disease, Inflammatory bowel disease, Level of evidence: IV, Ulcerative colitis
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-87844DOI: 10.1016/j.jpedsurg.2020.11.015ISI: 000712991700020PubMedID: 33276971Scopus ID: 2-s2.0-85097105172OAI: oai:DiVA.org:oru-87844DiVA, id: diva2:1507260
Note

Funding agencies:

HKH Kronprinsessan Lovisas förening

Sällskapet Barnavård

Janssen corporation

Available from: 2020-12-07 Created: 2020-12-07 Last updated: 2025-02-11Bibliographically approved

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Ludvigsson, Jonas F.

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