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PGC1α and VDAC1 expression in endometrial cancer
Division of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Department of Oncology-Pathology, BioClinicum, Karolinska Institute, Solna, Sweden.
Division of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden; Institute of Perinatology and Pediatrics, Almazov National Medical Research Centre, Saint-Petersburg, Russia.
Örebro University, School of Medical Sciences. Örebro University Hospital. Division of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
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2021 (English)In: Molecular and clinical oncology, ISSN 2049-9450, E-ISSN 2049-9469, Vol. 14, no 2, article id 42Article in journal (Refereed) Published
Abstract [en]

Endometrial cancer (EC) is one of the ten most common gynecological cancers. As in most cancers, EC tumour progression involves alterations in cellular metabolism and can be associated with, for instance, altered levels of glycolytic enzymes. Mitochondrial functions and proteins are known to serve key roles in tumour metabolism and progression. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1α) is a major regulator of mitochondrial biogenesis and function, albeit of varying prognostic value in different cancers. The voltage-dependent anion channel type 1 (VDAC1) regulates apoptosis as well as metabolite import and export over the mitochondrial outer membrane, and is often used for comparative quantification of mitochondrial content. Using immunohistochemistry, the present study examined protein expression levels of PGC1α and VDAC1 in tumour and paired benign tissue samples from 148 patients with EC, in order to examine associations with clinical data, such as stage and grade, Ki-67, p53 status, clinical resistance and overall survival. The expression levels of both PGC1α and VDAC1, as well as a PGC1α downstream effector, were significantly lower in tumor tissues than in benign tissues, suggesting altered mitochondrial function in EC. However, Kaplan-Meier, log rank and Spearman's rank correlation tests revealed that their expression was not correlated with survival and clinical data. Therefore, PGC1α and VDAC1 are not of major prognostic value in EC.

Place, publisher, year, edition, pages
Spandidos Publications , 2021. Vol. 14, no 2, article id 42
Keywords [en]
endometrial cancer, mitochondria, peroxisome proliferator-activated receptor gamma coactivator 1, voltage-dependent anion channel type 1, prognosis
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-88496DOI: 10.3892/mco.2020.2203ISI: 000607955300001PubMedID: 33437480Scopus ID: 2-s2.0-85099121751OAI: oai:DiVA.org:oru-88496DiVA, id: diva2:1518419
Funder
Swedish Cancer Society, 140373Stockholm County Council, SLL-562083Available from: 2021-01-15 Created: 2021-01-15 Last updated: 2021-01-29Bibliographically approved

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Mints, Miriam

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