Per and polyfluoroalkyl substances (PFASs) are a group of anthropogenic compounds that are being used widely in commercial and industrial products. These persistent and bioaccumulative compounds are distributed globally and have therefore gained increasing attention from researchers and regulators. They are found in different media such as air, water, sediment, and even in humans. An investigation and characterization of PFAS in wastewater including the variation of PFAS from different sampling sites at different time points from a hazardous waste management facility was carried out. In total, 24 samples from eight different sampling sites and three-time points were extracted for PFASs as well as for extractable organofluorine compounds (EOF) by solid-phase extraction (SPE) method and analyzed using ultra-performance liquid chromatography coupled with a tandem mass spectrometer (UPLC-MS/MS) for PFAS and combustion ion chromatography (CIC) for EOF. A mass balance approach was performed for the analysis of EOF. A total of 24 PFASs were investigated, and 15 of these showed detectable concentrations. The concentration of PFASs ranged from 0.780 ng/L to 8 890 ng/L. The samples from landfill leachate water showed higher concentrations while the production area (inside the waste facility) has lower concentration compared to other sites. The samples from each site showed a different concentration of PFASs at different sampling times. The concentrations also varied from site to site. The predominating compound was perfluorobutane sulfonic acid (PFBS) except for the production site (inside the waste facility) where Linear perfluorooctane sulfonic acid (L-PFOS) was the most abundant compound. The comparison between the composite (sum of sixteen samples from one sampling site) and the individual grab samples, indicated a lower concentration in the grab samples. Some PFASs, such as perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), and 4:2-fluorotelomer sulfonic acid (4:2 FTSA), were detected in the composite samples in very low concentrations, but not detected in the grab sample. Other compounds were detected in the grab samples in very low concentrations but not detected in composite samples, such as 8:2-FTSA and perfluoro-4-ethylcyclohexane sulfonate (PFECHS). For EOF, all the samples showed detectable concentrations ranging from 13.3 ng F/mL to 4690 ng F/mL in the water samples at a first sampling time point, 3.77 ng F/mL to 116 ng F/mL in the second sampling time, and 2.59 ng F/mL to 559 ng F/mL in third sampling time point. Contribution from detectable PFASs in EOF was 0.3% to 59%, which showed that many other unknown organofluorine compounds need to be investigated.