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An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring
Örebro University, School of Science and Technology. (Man-Technology-Environment Research Centre (MTM))ORCID iD: 0000-0002-3772-6978
MARBEC, Univ. Montpellier, CNRS, Ifremer, IRD, Route de Maguelone, Palavas-les-Flots, France; COISPA Tecnologia & Ricerca, Stazione Sperimentale per lo Studio delle Risorse del Mare, Italy.
MARBEC, Univ. Montpellier, CNRS, Ifremer, IRD, Route de Maguelone, Palavas-les-Flots, France.
MGX, Univ. Montpellier, CNRS, INSERM, Université Montpellier 2, Montpellier, France.
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2021 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 754, article id 142097Article in journal (Refereed) Published
Abstract [en]

Polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are persistent organic pollutants still present in aquatic environments despite their total or partial ban. Previously, we observed that an environmentally realistic mixture of these compounds affects energy balance, growth, and reproduction in exposed zebrafish (F0), and behavior in their unexposed offspring (F1-F4). In the present work, we performed lipidomic and transcriptomic analyses on brains of zebrafish (F0-F2) from exposed and control lineages to identify molecular changes that could explain the observed phenotypes. The use of both technologies highlighted that F0 zebrafish displayed impaired mitochondrial function and lipid metabolism regulation (depletion in triacylglycerols and phospholipids) which can explain disruption of energy homeostasis. A subset of the regulated biological pathways related to energetic metabolism and neurotransmission were inherited in 12. In addition, there were increasing effects on epigenetic pathways from the F0 to the F2 generation. Altogether, we show that the effects of an environmental exposure to PCBs and PBDEs on energetic metabolism as well as neurotransmission extend over 2 generations of zebrafish, possibly due to transgenerational epigenetic inheritance.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 754, article id 142097
Keywords [en]
Danio rerio, Persistent-organic pollutant, Neurotoxicity, Brain metabolism, RNA-Seq
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:oru:diva-88292DOI: 10.1016/j.scitotenv.2020.142097ISI: 000593899600029PubMedID: 32911150Scopus ID: 2-s2.0-85090281316OAI: oai:DiVA.org:oru-88292DiVA, id: diva2:1519685
Note

Funding Agencies:

French National Research Agency (ANR)ANR-13-CESA-020 ANR-10-INBS-09

Available from: 2021-01-19 Created: 2021-01-19 Last updated: 2021-01-19Bibliographically approved

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Blanc, MélanieHyötyläinen, Tuulia

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