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Loss of a co-twin at birth and subsequent risk of psychiatric disorders
West China Biomedical Big Data Center, West China Hospital, Sichuan University, Sichuan, China; Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-6851-3297
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychology, University of Southern California, Los Angeles, United States.
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2021 (English)In: eLIFE, E-ISSN 2050-084X, Vol. 10, article id e63514Article in journal (Refereed) Published
Abstract [en]

Twins suffering a co-twin loss at birth have reported feelings of loneliness and grief while it remains unexplored if they suffer increased risk of psychiatric disorders. We contrasted rate of first-onset psychiatric disorders among all Swedish-born twins whose co-twin died within 60 days after birth between 1973 and 2011 (n = 787) to that of 3935 matched unexposed twins, 3935 matched singletons (both matched to the exposed twins by birth year, sex, and birth characteristics), and 880 full siblings of the exposed twins. During a median of 19-year follow-up, exposed twins were at increased risk of first-onset psychiatric disorders (hazard ratio = 1.56, 95%CI 1.30-1.87) compared with unexposed twins. We observed the strongest association for emotional disorders and for psychiatric disorders diagnosed before the age of 25. Comparisons with matched singletons and the twin's full siblings rendered similar results, corroborating an association of loss of a co-twin at birth with subsequent risk of psychiatric disorders.

Place, publisher, year, edition, pages
eLife Sciences Publications Ltd , 2021. Vol. 10, article id e63514
Keywords [en]
Early twin loss, epidemiology, family design, global health, human, psychatric disorder
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-89078DOI: 10.7554/eLife.63514ISI: 000614092500001PubMedID: 33507148Scopus ID: 2-s2.0-85100104827OAI: oai:DiVA.org:oru-89078DiVA, id: diva2:1523769
Funder
Swedish Research Council, 340-2013-5867
Note

Funding Agencies:

Icelandic Centre for Research 163362-051

European Research Council (ERC) European Commission 726413

National Science Foundation (NSF) 81971262

Available from: 2021-01-29 Created: 2021-01-29 Last updated: 2021-03-03Bibliographically approved

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Larsson, Henrik

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