Psychiatric Disorders and Cardiovascular Diseases During the Diagnostic Workup of Suspected Prostate CancerShow others and affiliations
2021 (English)In: JNCI Cancer Spectrum, E-ISSN 2515-5091, Vol. 5, no 1, article id pkaa108Article in journal (Refereed) Published
Abstract [en]
Background: It is unknown whether the rate of psychiatric disorders and cardiovascular disease increases during the diagnostic workup of suspected prostate cancer.
Methods: We designed a population-based cohort study including 579 992 men living during 2005-2014 in Skåne, Sweden, according to the Swedish Total Population Register and the Skåne Healthcare Register (SHR). We used the Swedish Cancer Register and the SHR to identify all men with a new diagnosis of prostate cancer (N = 10 996), and all men underwent a prostate biopsy without receiving a cancer diagnosis (biopsy group, N = 20 482) as exposed to a diagnostic workup. Using Poisson regression, we compared the rates of psychiatric disorders and cardiovascular disease during the period before diagnosis or biopsy of exposed men with the corresponding rates of unexposed men.
Results: We found an increased rate of psychiatric disorders during the period before diagnosis or biopsy among men with prostate cancer (incidence rate ratio [IRR] = 1.87, 95% confidence interval [CI] = 1.67 to 2.10) and men in the biopsy group (IRR = 2.22, 95% CI = 2.08 to 2.37). The rate of cardiovascular disease increased during the period before diagnosis or biopsy among men with prostate cancer (IRR = 2.22, 95% CI = 2.12 to 2.32) and men in the biopsy group (IRR = 2.56, 95% CI = 2.49 to 2.63). Greater rate increases were noted for a diagnostic workup due to symptoms than due to other reasons.
Conclusions: There was an increased risk of psychiatric disorders and cardiovascular disease during the diagnostic workup of suspected prostate cancer regardless of the final cancer diagnosis.
Place, publisher, year, edition, pages
Oxford University Press, 2021. Vol. 5, no 1, article id pkaa108
National Category
Cancer and Oncology Urology and Nephrology
Identifiers
URN: urn:nbn:se:oru:diva-89459DOI: 10.1093/jncics/pkaa108ISI: 000648885600021PubMedID: 33554033Scopus ID: 2-s2.0-85115753045OAI: oai:DiVA.org:oru-89459DiVA, id: diva2:1526920
Funder
Swedish Cancer Society, CAN 2017/322Forte, Swedish Research Council for Health, Working Life and Welfare, 2017-00531
Note
Funding Agencies:
Karolinska Institutet (Senior Researcher Award)
Karolinska Institutet (Strategic Research Area in Epidemiology)
2021-02-092021-02-092023-12-08Bibliographically approved