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Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species
Institute of Biochemistry and Cell Biology, National Research Council, Napoli, Italy.
Institute for Biomedical Research and Innovation, National Research Council, Palermo, Italy.ORCID iD: 0000-0002-2403-7989
Department of Earth, Environment and Life Sciences, University of Genova, Genova, Italy.
Center for Plant Molecular Biology ‐ ZMBP, Eberhard‐Karls University Tübingen, Tübingen, Germany.
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2020 (English)In: Small, ISSN 1613-6810, Vol. 16, no 21, article id 2000598Article, review/survey (Refereed) Published
Abstract [en]

The interaction of a living organism with external foreign agents is a central issue for its survival and adaptation to the environment. Nanosafety should be considered within this perspective, and it should be examined that how different organisms interact with engineered nanomaterials (NM) by either mounting a defensive response or by physiologically adapting to them. Herein, the interaction of NM with one of the major biological systems deputed to recognition of and response to foreign challenges, i.e., the immune system, is specifically addressed. The main focus is innate immunity, the only type of immunity in plants, invertebrates, and lower vertebrates, and that coexists with adaptive immunity in higher vertebrates. Because of their presence in the majority of eukaryotic living organisms, innate immune responses can be viewed in a comparative context. In the majority of cases, the interaction of NM with living organisms results in innate immune reactions that eliminate the possible danger with mechanisms that do not lead to damage. While in some cases such interaction may lead to pathological consequences, in some other cases beneficial effects can be identified.

Place, publisher, year, edition, pages
Weinheim: Wiley - VCH Verlag GmbH , 2020. Vol. 16, no 21, article id 2000598
Keywords [en]
evolution, immunosafety, innate immunity, nanomaterials
National Category
Immunology
Identifiers
URN: urn:nbn:se:oru:diva-90376DOI: 10.1002/smll.202000598ISI: 000529890100001PubMedID: 32363795Scopus ID: 2-s2.0-85084242272OAI: oai:DiVA.org:oru-90376DiVA, id: diva2:1536797
Note

Funding Agencies:

EU H2020 project PANDORA GA 671881

European Commission GA 812661

Italian Ministry of Research Flagship project InterOmics  

Austrian FWF Doctoral Program W1213

Catalan Agencia de Gestio d'Ajuts Universitaris i de Recerca 2017-SGR-1431

Spanish Government RYC-2012-10991

Severo Ochoa program from Spanish MINECO SEV-2017-0706

CERCA Programme/Generalitat de Catalunya  

Ministry of Education, Youth & Sports - Czech Republic LO1509

Available from: 2021-03-12 Created: 2021-03-12 Last updated: 2023-05-16Bibliographically approved

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