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Sublethal effects of DBE-DBCH diastereomers on physiology, behavior, and gene expression of Daphnia magna
Örebro University, School of Science and Technology. (The Life Science Center-Biology)ORCID iD: 0000-0002-8841-8369
School of Science and Technology, Örebro University, Örebro, Sweden. (The Life Science Center-Biology)
Örebro University, School of Science and Technology. (The Life Science Center-Biology)ORCID iD: 0000-0002-2299-5024
Örebro University, School of Science and Technology. (The Life Science Center-Biology)ORCID iD: 0000-0001-7336-6335
2021 (English)In: Environmental Pollution, ISSN 0269-7491, E-ISSN 1873-6424, Vol. 284, article id 117091Article in journal (Refereed) Published
Abstract [en]

1,2-dibromo-4-(1,2-dibromoethyl)-cyclohexane (DBE-DBCH) is a brominated flame retardant used in commercial and industrial applications. The use of DBE-DBCH containing products has resulted in an increased release into the environment. However, limited information is available on the long-term effects of DBE-DBCH and its effects in aquatic invertebrates. Thus, the present study was aimed at determining how DBE-DBCH diastereomers (αβ and γδ) affects aquatic invertebrates using Daphnia magna as a model organism. Survival, reproduction, feeding, swimming behavior and toxicogenomic responses to environmental relevant concentrations of DBE-DBCH were analyzed. Chronic exposure to DBE-DBCH resulted in decreased lifespan, and reduced fecundity. Expression of genes involved in reproductive processes, vtg1 and jhe, were also inhibited. DBE-DBCH also induced hypoxia by inhibiting the transcription of genes involved in heme biosynthesis and oxygen transport. Furthermore, DBE-DBCH also inhibited feeding resulting in emptiness of the alimentary canal. Increased expression of the stress response biomarkers was observed following DBE-DBCH exposure. In addition, DBE-DBCH diastereomers also altered the swimming behavior of Daphnia magna. The present study demonstrates that DBE-DBCH cause multiple deleterious effects on Daphnia magna, including effects on reproduction and hormonal systems. These endocrine disrupting effects are in agreement with effects observed on vertebrates. Furthermore, as is the case in vertebrates, DBE-DBCH γδ exerted stronger effects than DBE-DBCH αβ on Daphnia magna. This indicate that DBE-DBCH γδ has properties making it more toxic to all so far studied animals than DBE-DBCH αβ.

Place, publisher, year, edition, pages
Springer, 2021. Vol. 284, article id 117091
Keywords [en]
Brominated flame retardant, Gene expression, Longevity, Reproduction, TBECH, Toxicogenomic
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:oru:diva-91484DOI: 10.1016/j.envpol.2021.117091ISI: 000672531100007PubMedID: 33901980Scopus ID: 2-s2.0-85104649107OAI: oai:DiVA.org:oru-91484DiVA, id: diva2:1547753
Funder
Knowledge Foundation, 20150084 20180027
Note

Funding agency:

Örebro University

Available from: 2021-04-28 Created: 2021-04-28 Last updated: 2024-01-02Bibliographically approved

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Seyoum, AsmeromPaylar, BerkayOlsson, Per-Erik

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