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Novel Experimental Technique to Create Size-Controlled Retroperitoneal Bleeding in the Infrarenal Aorta of Anesthetized Pigs
Department of Cardiothoracic and Vascular Surgery, Linköping University Hospital, Sweden.
Department of Surgery, Höglandssjukhuset Eksjö, Region Jönköping County Council, Sweden.
Örebro University, School of Medical Sciences. Department of Surgery.
Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University, Sweden.
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2021 (English)In: Innovations (Philadelphia): technology and techniques in cardiothoracic and vascular surgery, ISSN 1556-9845, E-ISSN 1559-0879, Vol. 16, no 4, p. 379-385Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Rupture of abdominal aortic aneurysm (rAAA) with a contained retroperitoneal hematoma is potentially fatal. Physiological studies are difficult to perform in patients suffering from life-threatening conditions such as rAAA. A translational model of the condition is therefore needed. The aim was to develop and validate an endovascular animal model for retroperitoneal bleeding of the abdominal aorta with contained hematoma.

METHODS: = 6). Onset of bleeding was verified by angiography and macroscopically examined on completion of the experiments. Survival up to 180 min was the primary outcome. Hemodynamic and metabolic markers in arterial blood were secondary outcomes.

RESULTS: = 0.002), but not when comparing the 6 mm and 8 mm groups. Systemic hypotension, arterial acidosis, and lactatemia were provoked in the 6 mm and 8 mm groups but not in the 4 mm group.

CONCLUSIONS: A porcine model for a controlled contained left posterolateral retroperitoneal bleeding was created using endovascular methods and validated. This model makes it possible to study the pathophysiology of a retroperitoneal hematoma.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2021. Vol. 16, no 4, p. 379-385
Keywords [en]
Endovascular surgery, experimental animal model, physiology of shock, retroperitoneal hematoma, ruptured abdominal aortic aneurysm
National Category
Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:oru:diva-92121DOI: 10.1177/15569845211013803ISI: 000693679300014PubMedID: 34077271Scopus ID: 2-s2.0-85107203250OAI: oai:DiVA.org:oru-92121DiVA, id: diva2:1559933
Available from: 2021-06-03 Created: 2021-06-03 Last updated: 2021-09-17Bibliographically approved

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Wallin, GöranNilsson, Kristofer F.

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