Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction: Rationale and design of the EURO-ICE trialShow others and affiliations
2021 (English)In: EuroIntervention, ISSN 1774-024X, E-ISSN 1969-6213, Vol. 16, no 17, p. 1444-1446Article in journal (Refereed) Published
Abstract [en]
In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect.
Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method.
Place, publisher, year, edition, pages
European Society of Cardiology , 2021. Vol. 16, no 17, p. 1444-1446
National Category
Cardiology and Cardiovascular Disease
Identifiers
URN: urn:nbn:se:oru:diva-92218DOI: 10.4244/EIJ-D-19-00471ISI: 000654749700012PubMedID: 31498112Scopus ID: 2-s2.0-85104901490OAI: oai:DiVA.org:oru-92218DiVA, id: diva2:1562002
Note
Funding Agency:
Abbott Laboratories
2021-06-082021-06-082025-02-10Bibliographically approved