Silica Dust Exposure Increases Risk for Rheumatoid Arthritis: A Swedish National Registry Case-Control StudyShow others and affiliations
2021 (English)In: Journal of Occupational and Environmental Medicine, ISSN 1076-2752, E-ISSN 1536-5948, Vol. 63, no 11, p. 951-955Article in journal (Refereed) Published
Abstract [en]
OBJECTIVE: Rheumatoid arthritis (RA) is an inflammatory disease with unknown etiology. This study examines if silica dust exposure increases the risk for seropositive and seronegative RA.
METHODS: A nationwide registry case-control study was conducted that included all cases of RA in Sweden between 2005 and 2016. In total, 31,139 cases with two matched controls were included. A JEM was used to estimate exposure.
RESULTS: Silica dust exposure was associated with a statistically significant increase in odds ratio (OR) for seropositive (OR 1.22, 95% CI 1.05 to 1.40) and seronegative (OR 1.23, 95% CI 1.04 to 1.46) RA among men.
CONCLUSION: This study found an increased OR for RA in silica-exposed men. The OR was equal for seropositive and seronegative RA. These findings further support the hypothesis that silica dust may be a trigger for RA.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2021. Vol. 63, no 11, p. 951-955
Keywords [en]
case-control study, occupational exposure, rheumatoid arthritis, silica
National Category
Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:oru:diva-92184DOI: 10.1097/JOM.0000000000002281ISI: 000714714600027PubMedID: 34091575OAI: oai:DiVA.org:oru-92184DiVA, id: diva2:1562004
Funder
Region Örebro County2021-06-082021-06-082024-01-02Bibliographically approved