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Hepatobiliary malignancy surveillance strategies in primary sclerosing cholangitis associate with reduced mortality
Karolinska University Hospital, Department of Medicine Huddinge, Unit of Gastroenterology and Rheumatology, Huddinge, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.ORCID iD: 0000-0002-0942-0816
Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany; University Hospital Essen, University of Duisburg-Essen, Department of Gastroenterology and Hepatology, Essen, Germany.
Number of Authors: 452021 (English)In: Journal of Hepatology, ISSN 0168-8278, E-ISSN 1600-0641, Vol. 75, no Suppl. 2, p. S227-S228Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background and aims: Patients with primary sclerosing cholangitis (PSC) are at increased risk for hepatobiliary malignancies, especially cholangiocarcinoma. Although many recommend surveillance for malignancy in PSC, different strategies are used by various centers and countries. We aimed to evaluate different surveillance strategies and their effectiveness in PSC with the hypothesis that surveillance imaging improves survival.

Method: We queried centers about surveillance practices and retrospectively collected imaging surveillance data for hepatobiliary cancer in 2, 975 patients with PSC from 28 centers within the International PSC Study Group (IPSCSG). Surveillance strategies were grouped in (i) non-surveillance (no imaging in asymptomatic patients), (ii) magnetic resonance imaging (MRI) and/or ultrasound (US) surveillance (regular imaging regardless of symptoms/labs) and (iii) surveillance including endoscopic retrograde cholangiopancreatography (ERCP)-based (imaging and/or ERCP regardless of symptoms/labs). The primary end point was all-cause mortality. Cox-proportional hazard regression models were used to estimate hazard ratios (HRs).

Results: 65.6% (1953/2975) of patients were male, mean age (SD) at diagnosis of PSC was 35.6 (14.2) years, with concomitant IBD in 71.5% (2127/2973). Hepatobiliary malignancy was found in 175 (5.9%) patients at 7.9 years of follow-up (Figure). Surveillance strategies differed significantly between centers. Of patients undergoing surveillance, 83% were subjected to MRI/MRCP, 49% to US and 28% to ERCP. Deaths were more frequent in the non-surveillance group 23.4% (82/350) than in the surveillance group 8.3% (218/2625). Mortality rate (95% CI) per 1000 person-years was 23.1 (18.1–28.1) inthe non-surveillance group (n = 350), 12.5 (10.6–14.5) in imaging surveillance with MRI and/or US (n = 1897) and 8.4 (6.3–10.5) in surveillance that included ERCP (n = 728). The risk of dying wasr educed in patients undergoing any type of surveillance (HR 0.53; 95% CI: 0.41–0.68) and the reduced risk remained after adjusting for sex, age and start year of follow-up (HR 0.61; 95% CI: 0.47–0.80).

Conclusion: A broad variety of surveillance strategies across centers are used. Regular sur veillance for hepatobiliary malignancy in patients with PSC is associated with improved survival.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 75, no Suppl. 2, p. S227-S228
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-93391ISI: 000667753800053OAI: oai:DiVA.org:oru-93391DiVA, id: diva2:1583309
Conference
The International Liver Congress, (Digital congress), June 23–26, 2021
Available from: 2021-08-05 Created: 2021-08-05 Last updated: 2021-08-05Bibliographically approved

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Nyhlin, Nils

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