Radiotherapy as Elective Treatment of the Node-negative Neck in Oral Squamous Cell CancerShow others and affiliations
2021 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 41, no 7, p. 3489-3498Article in journal (Refereed) Published
Abstract [en]
BACKGROUND/AIM: Previous studies of node-negative oral squamous cell carcinoma have shown a benefit of elective neck dissection compared to observation. Evidence for radiotherapy as single-modality elective treatment of the node-negative neck is so far lacking.
PATIENTS AND METHODS: In a retrospective material of 420 early-stage oral cancers from 2000 to 2016, overall survival, disease-free survival, and regional relapse-free survival were calculated with the Kaplan-Meier method.
RESULTS: At five years, overall survival was 59.7%, disease-specific survival was 77.2%, and regional relapse-free survival was 83.5%. Among those with adjuvant treatment of the neck after surgery of T1-T2 tumours during 2009-2016, regional relapse-free survival at five years was 85.7% for elective radiotherapy of the neck and 87.4% for elective neck dissection.
CONCLUSION: Elective radiotherapy to the neck with a modern technique and adequate dose might be an alternative to neck dissection for patients with early-stage oral squamous cell cancer.
Place, publisher, year, edition, pages
International Institute of Anticancer Research, 2021. Vol. 41, no 7, p. 3489-3498
Keywords [en]
Head and neck cancer, adjuvant radiotherapy, neck dissection, oral cancer, quality register, radiotherapy, squamous cell carcinoma
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-93534DOI: 10.21873/anticanres.15136ISI: 000677481500004PubMedID: 34230144Scopus ID: 2-s2.0-85109249456OAI: oai:DiVA.org:oru-93534DiVA, id: diva2:1583908
Note
Funding Agecies:
Region Örebro Län
Örebro University, Örebro, Sweden
2021-08-102021-08-102021-08-17Bibliographically approved