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Genetic Influence on Nociceptive Processing in the Human Brain: A Twin Study
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Psychology and Social Work, Mid Sweden University, Östersund, Sweden.
Department of Psychology and Social Work, Mid Sweden University, Östersund, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Biomedical Data Sciences, Leiden University Medical Center, RA, Leiden, the Netherlands.
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2022 (English)In: Cerebral Cortex, ISSN 1047-3211, E-ISSN 1460-2199, Vol. 32, no 2, p. 266-274Article in journal (Refereed) Published
Abstract [en]

Nociceptive processing in the human brain is complex and involves several brain structures and varies across individuals. Determining the structures that contribute to interindividual differences in nociceptive processing is likely to improve our understanding of why some individuals feel more pain than others. Here, we found specific parts of the cerebral response to nociception that are under genetic influence by employing a classic twin-design. We found genetic influences on nociceptive processing in the midcingulate cortex and bilateral posterior insula. In addition to brain activations, we found genetic contributions to large-scale functional connectivity (FC) during nociceptive processing. We conclude that additive genetics influence specific brain regions involved in nociceptive processing. The genetic influence on FC during nociceptive processing is not limited to core nociceptive brain regions, such as the dorsal posterior insula and somatosensory areas, but also involves cognitive and affective brain circuitry. These findings improve our understanding of human pain perception and increases chances to find new treatments for clinical pain.

Place, publisher, year, edition, pages
Oxford University Press, 2022. Vol. 32, no 2, p. 266-274
Keywords [en]
fMRI, functional connectivity, genetics, nociception, pain
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:oru:diva-93510DOI: 10.1093/cercor/bhab206ISI: 000743158600002PubMedID: 34289027Scopus ID: 2-s2.0-85126580425OAI: oai:DiVA.org:oru-93510DiVA, id: diva2:1583972
Funder
Swedish Research Council, 2014-01160 2018-01322Available from: 2021-08-10 Created: 2021-08-10 Last updated: 2023-12-08Bibliographically approved

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