To Örebro University

oru.seÖrebro University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Estradiol Alters the Virulence Traits of Uropathogenic Escherichia coli
Örebro University, School of Medical Sciences.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Research and Education.
Örebro University, School of Medical Sciences. (iRiSC-Inflammatory Response and Infection Susceptibility Centre)
2021 (English)In: Frontiers in Microbiology, E-ISSN 1664-302X, Vol. 12, article id 682626Article in journal (Refereed) Published
Abstract [en]

Uropathogenic Escherichia coli (UPEC) is the most common bacteria to cause urinary tract infection (UTI). Postmenopausal women have an increased risk of recurrent UTI. This is partly explained by estrogenic effects on host defenses against UTI. Current research is mostly focused on how UPEC affects host factors, but not so much is known about how host factors like hormones affect UPEC virulence. The aim of the present study was to investigate the impact of estradiol exposure on the virulence of UPEC. We found that a postmenopausal concentration of estradiol increased CFT073 growth and biofilm formation, but not the premenopausal concentrations. Real-time qPCR showed that estradiol altered the expression of genes associated with the iron acquisition system and metabolic pathways in CFT073. We also found that estradiol in a dose-dependent manner increased the expression of fimH and papC adhesins and increased colonization and invasion of bladder epithelial cells. The premenopausal concentration of estradiol also suppressed cytokine release from bladder epithelial cells. Additionally, we also showed using a Caenorhabditis elegans killing assay that estradiol increased the survival of CFT073-infected C. elegans worms. Taken together, our findings show that estradiol has the ability to alter the virulence traits of UPEC.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2021. Vol. 12, article id 682626
Keywords [en]
Cross-kingdom interaction, estradiol, growth, uropathogenic Escherichia coli, virulence
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-93506DOI: 10.3389/fmicb.2021.682626ISI: 000680489400001PubMedID: 34354683Scopus ID: 2-s2.0-85111918637OAI: oai:DiVA.org:oru-93506DiVA, id: diva2:1583983
Note

Funding Agencies:

Faculty of Medicine and Health at Örebro University

Research Committee of Örebro County Council

Available from: 2021-08-10 Created: 2021-08-10 Last updated: 2024-01-17Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records

Engelsöy, UlrikSvensson, MariaDemirel, Isak

Search in DiVA

By author/editor
Engelsöy, UlrikSvensson, MariaDemirel, Isak
By organisation
School of Medical SciencesÖrebro University Hospital
In the same journal
Frontiers in Microbiology
Microbiology in the medical area

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 153 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf