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Human exposure to perfluorinated chemicals through the diet: intake of perfluorinated compounds in foods from the Catalan (Spain) market
Örebro University, School of Science and Technology. (MTM)ORCID iD: 0000-0002-6330-789X
Örebro University, School of Science and Technology. (MTM)ORCID iD: 0000-0001-6217-8857
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2008 (English)In: Journal of Agricultural and Food Chemistry, ISSN 0021-8561, E-ISSN 1520-5118, Vol. 56, no 5, p. 1787-1794Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to determine the dietary intake of perfluorinated chemicals (PFCs) by the population of Tarragona County (Catalonia, Spain). PFC levels were determined in 36 composite samples of foodstuffs randomly purchased in various locations. Exposure to PFCs through the diet was estimated for various age/gender groups. Perfluorooctane sulfonate (PFOS), perfluorocarboxylate perfluorooctanoate (PFOA), and perfluoroheptanoic acid (PFHpA) were the only detected PFCs in foodstuffs. On average, for a standard adult man (70 kg of body weight), the dietary intake of PFOS was estimated to be 62.5 or 74.2 ng/day (assuming ND=0 or ND=1/2 LOD, respectively). Fish, followed by dairy products and meats, were the main contributors to PFOS intake. For an adult man, the intake of PFOS (1.07 ng/kg/day) and those of PFOA and PFHpA were lower than that recently reported for Canada (4.0 ng/kg/day), and considerably lower than that previously found in the United Kingdom, the only two countries where, to date, results concerning this issue have been reported. A correlation between dietary intake and blood levels of PFOS is suggested. However, the current results do not justify dietary intake as the main route of exposure governing blood concentrations of other PFCs.

Place, publisher, year, edition, pages
2008. Vol. 56, no 5, p. 1787-1794
National Category
Natural Sciences Chemical Sciences Environmental Sciences
Research subject
Chemistry; Environmental Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-5299DOI: 10.1021/jf0732408PubMedID: 18251500OAI: oai:DiVA.org:oru-5299DiVA, id: diva2:158655
Available from: 2009-02-03 Created: 2009-02-03 Last updated: 2017-12-14Bibliographically approved
In thesis
1. Assessment of human exposure to per- and polyfluorinated compounds (PFCs): exposure through food, drinking water, house dust and indoor air
Open this publication in new window or tab >>Assessment of human exposure to per- and polyfluorinated compounds (PFCs): exposure through food, drinking water, house dust and indoor air
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Per- and polyfluorinated compounds (PFCs) are detected in humans worldwide but all sources of human exposure have not been fully characterized. The aim of this thesis was to evaluate the contributions from food, water, air and dust as sources for human PFC exposure in the general population.

Per- and polyfluorinated compounds (PFCs) are detected in humans worldwide but all sources of Up to 27 PFCs were determined at trace levels in blood (ng/mL), water (ng/L), foods (ng/g), dust (ng/g) and air (pg/m3) in a selected Catalan population and PFC intake was estimated from the measured PFC concentrations of the different sources of exposure.

The major compounds detected in human blood of the studied population were perfluorooctane sulfonate (PFOS; 7.6 ng/mL), perfluorohexane sulfonate (PFHxS; 3.6 ng/mL) and perfluorooctanoic acid (PFOA; 1.8 ng/mL). In general, PFOS was also the major compound detected in most sources of exposure.

Food was found to be the dominant pathway for human PFC exposure accounting for more than 70 % of the total intake of both PFOS and PFOA. In the most populated area (the Barcelona Province) where the highest levels were measured, tap water can contribute to the total exposure substantially with more than 50 % for adults. Indoor sources were negligible in the selected area for most PFCs when compared to food and water intake, except for toddlers under a worst case scenario where contribution from dust and food intake were equal (19 %).

Pharmacokinetic (PK) modelling resulted in exposure of 103 ng PFOS/day and 33 ng PFOA/day of adults from the internal PFC blood concentrations. This agrees well with the intake estimated from external exposure through food, drinking water, house dust and indoor air of 80 ng PFOS/day and 32 ng PFOA/day and evidently all major exposure sources for the general population were included (in this study).

Place, publisher, year, edition, pages
Örebro: Örebro universitet, 2011. p. 85
Series
Örebro Studies in Chemistry, ISSN 1651-4270 ; 10
Keyword
human exposure, per- and polyfluorinated compunds (PFCs), dietary intake, drinking water, indoor environment
National Category
Earth and Related Environmental Sciences Environmental Sciences Chemical Sciences
Research subject
Environmental Chemistry; Chemistry
Identifiers
urn:nbn:se:oru:diva-16624 (URN)978-91-7668-811-3 (ISBN)
Public defence
2011-09-23, Örebro universitet, Hörsal M, Fakultetsgatan 1, Örebro, 10:00 (English)
Opponent
Supervisors
Available from: 2011-08-24 Created: 2011-08-24 Last updated: 2017-10-17Bibliographically approved

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Ericson Jogsten, Ingridvan Bavel, BertLindström, Gunilla

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