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Biomarker responses and decreasing contaminant levels in ringed seals (Pusa hispida) from Svalbard, Norway
Örebro University, School of Science and Technology. (MTM)ORCID iD: 0000-0001-6217-8857
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2008 (English)In: Journal of Toxicology and Environmental Health, ISSN 1528-7394, E-ISSN 1087-2620, Vol. 71, no 15, p. 1009-1018Article in journal (Refereed) Published
Abstract [en]

Blubber was analyzed for a wide range of contaminants from five sub-adult and eight adult male ringed seals sampled in 2004, namely, for polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), toxaphenes, chlordanes, dichlorodiphenyldichloroethylene (DDE), and polybrominated diphenylethers (PBDEs). Contaminant levels were compared to previously sampled animals from the same area, as well as data from literature for other arctic wildlife species from a wide variety of locations. Ringed seals sampled in 2004 showed 50-90% lower levels of legacy contaminants such as PCBs and chlorinated pesticides compared to animals sampled in 1996 of similar age (14 sub-adults and 7 adult males), indicating that the decline of chlorinated contaminants observed during the 1990s in a variety of arctic wildlife species is continuing into the 21st century. The results also indicated that PBDE declined in ringed seals; levels in 2004 were about 70-80% lower than in animals sampled in 1998. This is one of the first observations of reduced exposure to these compounds and might be a first indication that restrictions of production and use of these contaminants have resulted in lower exposures in the Arctic. The PCB pattern shifted toward the less chlorinated (i.e., less persistent) PCBs, especially in adult ringed seals, possibly as a result of reduced overall contaminant exposures and a consequently lower cytochrome P-450 (CYP) induction, which results in a slower metabolism of less persistent PCBs. The overall effect would be relative increases in the lower chlorinated PCBs and a relative decreases in the higher chlorinated PCB. Possibly due to low exposure and consequent low induction levels, ethoxyresorufin O-deethylation (EROD) activity proved to be a poor biomarker for contaminant exposure in ringed seals in the present study. The close negative correlation (r(2) = 70.9%)between EROD activity and percent blubber indicates that CYP might respond to increased bioavailability of the contaminant mixtures when they are mobilized from blubber during periods of reduced food intake.

Place, publisher, year, edition, pages
2008. Vol. 71, no 15, p. 1009-1018
National Category
Natural Sciences Environmental Sciences
Research subject
Chemistry
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URN: urn:nbn:se:oru:diva-5302DOI: 10.1080/15287390801907558PubMedID: 18569610OAI: oai:DiVA.org:oru-5302DiVA, id: diva2:158664
Available from: 2009-02-03 Created: 2009-02-03 Last updated: 2017-12-14Bibliographically approved

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van Bavel, Bert

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