The European Family Support Network (EurofamNet) is a bottom-up, evidence-based, multidisciplinary network funded as an Action (CA18123) under the COST program. EurofamNet aims to inform family policies and practices by reflecting common goals across participating countries, while recognizing the specific nature of families’ cultural and socio-economic contexts within them. In this chapter, some of the most salient outputs developed in EurofamNet up to now are briefly described. These outputs cover three key areas that currently constitute research challenges in family support agenda: (1) quality assurance in child and family support services and in the standards for best practices in matters of design, implementation and evaluation of family support programmes; (2) agreement on the skills qualification for family support workforce necessary for a high quality services delivery in working with families; (3) and frontier- knowledge responses to parenting across the life-course and in particular to challenges faced by families in difficult situations. In these areas, contributions from EurofamNet are summarized and remaining challenges are highlighted.