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Attention-deficit/hyperactivity disorder and Alzheimer's disease and any dementia: A multi-generation cohort study in Sweden
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Medical Sciences.ORCID iD: 0000-0002-3887-9669
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2022 (English)In: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 18, no 6, p. 1155-1163Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: We examined the extent to which attention-deficit/hyperactivity disorder (ADHD), a neurodevelopmental disorder, is linked with Alzheimer's disease (AD) and any dementia, neurodegenerative diseases, across generations.

METHODS: A nationwide cohort born between 1980 and 2001 (index persons) were linked to their biological relatives (parents, grandparents, uncles/aunts) using Swedish national registers. We used Cox models to examine the cross-generation associations.

RESULTS: Among relatives of 2,132,929 index persons, 3042 parents, 171,732 grandparents, and 1369 uncles/aunts had a diagnosis of AD. Parents of individuals with ADHD had an increased risk of AD (hazard ratio 1.55, 95% confidence interval 1.26-1.89). The associations attenuated but remained elevated in grandparents and uncles/aunts. The association for early-onset AD was stronger than late-onset AD. Similar results were observed for any dementia.

DISCUSSION: ADHD is associated with AD and any dementia across generations. The associations attenuated with decreasing genetic relatedness, suggesting shared familial risk between ADHD and AD.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022. Vol. 18, no 6, p. 1155-1163
Keywords [en]
Alzheimer's disease, dementia, epidemiology, family design, neurodevelopmental disorder
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-94354DOI: 10.1002/alz.12462ISI: 000694001700001PubMedID: 34498801Scopus ID: 2-s2.0-85114479246OAI: oai:DiVA.org:oru-94354DiVA, id: diva2:1594894
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2019-00176 2019-01172Swedish Research Council, 2018-02599European Commission, 1754285The Swedish Brain Foundation, FO2018-0273Available from: 2021-09-16 Created: 2021-09-16 Last updated: 2023-03-28Bibliographically approved

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Dobrosavljevic, MajaLarsson, Henrik

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