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Antiepileptic medicines in men and women with stroke in Sweden, a registry-based study
Health and Medical Care Administration Region Stockholm, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0002-3845-8100
2021 (English)In: Health Science Reports, E-ISSN 2398-8835, Vol. 4, no 4, article id e405Article in journal (Refereed) Published
Abstract [en]

Background and aim: To describe the utilization of the first antiepileptic drug (AED) in men and women with previous stroke in a nationwide population.

Methods: Prescription data, patient's age, and sex were collected from the Swedish Drug Register and cross-linked to diagnosis data from the National Patient Register and data from Statistics Sweden. Patients with a first dispensation of an AED after stroke between 1 January 2007 and 31 December 2014 were included.

Results: A total of 10 958 patients with stroke were initiated on AED treatment (51% women, mean age 75 years). Gabapentin (n = 3073, 28%), pregabalin (n = 2476, 22%), carbamazepine (n = 2330, 21%), levetiracetam (n = 1158, 10%), and valproic acid (n = 833, 7%) were the most dispensed AEDs. After stratification by the presence of a neuropathic pain diagnosis, gabapentin, and pregabalin were the most used AEDs. In contrast, after stratification for epilepsy/convulsions diagnosis, carbamazepine and levetiracetam were the most initiated AEDs.

Conclusion: This study suggests that AED is mainly used for neuropathic/poststroke pain and the study shows gabapentin and pregabalin to be the most used AEDs. For epilepsy, carbamazepine and levetiracetam were the most used AEDs in patients with previous stroke.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021. Vol. 4, no 4, article id e405
Keywords [en]
Antiepileptic drugs, poststroke epilepsy, sex differences
National Category
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-94872DOI: 10.1002/hsr2.405ISI: 000735431100075PubMedID: 34622031Scopus ID: 2-s2.0-85121877920OAI: oai:DiVA.org:oru-94872DiVA, id: diva2:1601833
Funder
Region Stockholm, 20180302Available from: 2021-10-11 Created: 2021-10-11 Last updated: 2024-01-02Bibliographically approved

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