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Mammographic Density Changes over Time and Breast Cancer Risk: A Systematic Review and Meta-Analysis
Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden.
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Oncology.ORCID iD: 0000-0001-6059-0194
2021 (English)In: Cancers, ISSN 2072-6694, Vol. 13, no 19, article id 4805Article, review/survey (Refereed) Published
Abstract [en]

The aim of this meta-analysis was to evaluate the association between mammographic density changes over time and the risk of breast cancer. We performed a systematic literature review based on the PubMed and ISI Web of Knowledge databases. A meta-analysis was conducted by computing extracted hazard ratios (HRs) and 95% confidence intervals (CIs) for cohort studies or odds ratios (ORs) and 95% confidence interval using inverse variance method. Of the nine studies included, five were cohort studies that used HR as a measurement type for their statistical analysis and four were case-control or cohort studies that used OR as a measurement type. Increased breast density over time in cohort studies was associated with higher breast cancer risk (HR: 1.61; 95% CI: 1.33-1.96) whereas decreased breast density over time was associated with lower breast cancer risk (HR: 0.78; 95% CI: 0.71-0.87). Similarly, increased breast density over time was associated with higher breast cancer risk in studies presented ORs (pooled OR: 1.85; 95% CI: 1.29-2.65). Our findings imply that an increase in breast density over time seems to be linked to an increased risk of breast cancer, whereas a decrease in breast density over time seems to be linked to a lower risk of breast cancer.

Place, publisher, year, edition, pages
MDPI, 2021. Vol. 13, no 19, article id 4805
Keywords [en]
Breast cancer risk, breast density, mammography, meta-analysis
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-95012DOI: 10.3390/cancers13194805ISI: 000707207600001PubMedID: 34638289Scopus ID: 2-s2.0-85115769219OAI: oai:DiVA.org:oru-95012DiVA, id: diva2:1602948
Available from: 2021-10-14 Created: 2021-10-14 Last updated: 2021-10-28Bibliographically approved

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Valachis, Antonis

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